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> α-Thujone [546-80-5]

α-Thujone [546-80-5]

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Référence orb1299134-10mg

Conditionnement : 10mg

Marque : Biorbyt

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α-Thujone

SKU: orb1299134

Description

α-Thujone is a small molecule inhibitor of acetylcholinesterase (AChE) with an IC50 of 24.7 µM. It is used in neuroscience research to study cholinergic signaling and has been investigated in vitro for its neuroactive properties.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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α-Thujone

Key Properties

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CAS Number546-80-5
MW152.23
Purity98.41% (May vary between batches)
FormulaC10H16O
SMILES00[C@]12C[C@]1(CC(=O)[C@@H]2C)C(C)C
TargetROS,Reactive Oxygen Species,GABA Receptor,Parasite,Autophagy,Apoptosis,AChR
SolubilityDMSO:4.4 mg/mL (28.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (6.57 mM)

Bioactivity

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Target IC50
α7 nAChR:24.7μM
In Vitro
In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Apoptosis, a-Thujone, Autophagy, anthelmintic, antinociceptive, anti-invasive, anti-tumor, ALPHA-(-)-THUJONE, ALPHA-THUJONE, BBB, AChR, GABAReceptor, GABA Receptor, GABAA, Gamma-aminobutyric acid Receptor, insecticidal, Parasite, Inhibitor, inhibit, Monoterpene, α Thujone, αThujone, α-Thujone, γ-Aminobutyric acid Receptor, ROS, stress, oxidative, Thujone, ReactiveOxygenSpecies, Reactive Oxygen Species, pro-apoptotic

Compound Identifiers

PubChem CID
261491 ↗

Key Properties

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Protocol Information