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> 5-Methoxysterigmatocystin [22897-08-1]

5-Methoxysterigmatocystin [22897-08-1]

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Référence 207021-1mg

Conditionnement : 1mg

Marque : US Biological

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207021 5-Methoxysterigmatocystin

Grade
Highly Purified
Shipping Temp
RT
Storage Temp
-20°C

Mycotoxin. Derivative of sterigmatocystin. Carcinogenic activity. Anticancer compound. Cytotoxic and genotoxic.

Synonyms:
5-Ms; Nsc178249; 5-Methoxysterigmatocysin; 11-Methoxysterigmatocystin, (3aR)-3aβ,12cβ-Dihydro-8-hydroxy-6,11-dimethoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one; (3aR,12cS)-3a,12c-Dihydro-8-hydroxy-6,11-dimethoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one

CAS Number:
22897-08-1

Source:
Aspergillus sp. (strain WDMH51)

Molecular Formula:
C₁₉H₁₄O₇

Solubility:
Chloroform and DMSO.

Method for Determining Identity:
Proton NMR

Molecular Weight:
354.3

Appearance:
Supplied as a pale yellow powder.

Purity:
≥98% (HPLC; NMR)

Storage and Stability:
May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
Supplied as a pale yellow powder.
Purity
≥98% (HPLC; NMR)
References
1. 5-Methoxysterigmatocystin, a metabolite from a mutant strain of Aspergillus vericolor: J. S. E. Holker & S. A. Kagal; Chem. Commun. 1968: 1574 (1968). 2. Fermentation, isolation, and antitumor activity of sterigmatocystins: W.T. Bradner, et al.; Antimicrob. Agents Chemother. 8: 159 (1975). 3. Preparation and antitumor activities of some derivatives of 5-methoxysterigmatocystin: J.M. Essery, et al.; J. Med. Chem. 19: 1339 (1976). 4. 1H and 13C NMR assignments for two anthraquinones and two xanthones from the mangrove fungus ZSUH- 36: C. Shao, et al.; Magn. Reson. Chem. 45: 434 (2007). 5. Sterigmatocystins from deep-sea-derived fungus Aspergillus versicolor: C. Shengxin, et al.; J. Antibiot. 64: 193 (2011). 6. Cytotoxicity and genotoxicity of versicolorins and 5-methoxysterigmatocystin in A549 cells: D. Jksic et al.; Arch. Toxicol. 86: 1583 (2012)