ACC alpha Antibody
Référence MBS8584049-0,1mL-Biotin
Conditionnement : 0.1mL(Biotin)
Marque : MyBiosource
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ACC Alpha (ACCalpha) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8584049MBS8584049 is an antibody targeting ACCalpha. Also known as ACC alpha Antibody. Reactive in Human, Mouse, Rat, Bovine, Chicken, Sheep. Host: Rabbit. Rabbit polyclonal antibody to ACC alpha More details
Product Overview
Online Datasheet in PDFProduct Name
ACC alpha (ACCalpha), Polyclonal Antibody
Full Product Name
ACC alpha Antibody
Product Gene Name
anti-ACCalpha antibody
Product Synonym Gene Name
ACACA
Product Synonym Names
ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of ACC alpha protein.
Molecular Weight
265,554 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (35441927..35766902, complement). Location: 17q21
OMIM
200350
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ACC alpha. The exact sequence is proprietary.
Product Categories/Family for anti-ACCalpha antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ACCalpha antibody
Western Blot (WB), Immunohistochemistry (IHC)
Other Notes
Small volumes of anti-ACCalpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ACCalpha. It may not necessarily be applicable to this product.
NCBI Official Full Name
acetyl-CoA carboxylase 1 isoform 1
NCBI Official Synonym Full Names
acetyl-CoA carboxylase alpha
NCBI Official Symbol
ACACA
NCBI Official Synonym Symbols
ACC; ACAC; ACC1; ACCA; ACACAD
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alpha
UniProt Gene Name
ACACA
UniProt Synonym Gene Names
ACAC; ACC1; ACCA; ACC1
UniProt Entry Name
ACACA_HUMAN
NCBI Protein Information
acetyl-CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha
NCBI Summary for ACCalpha
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ACCalpha
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.
Protein type: Ligase; EC 6.3.4.14; EC 6.4.1.2; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding
Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; multicellular organismal protein metabolic process; tissue homeostasis; positive regulation of cellular metabolic process; energy reserve metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; carnitine shuttle; cellular lipid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process; biotin metabolic process; protein homotetramerization
Disease: Acetyl-coa Carboxylase Deficiency
Show more Protein type: Ligase; EC 6.3.4.14; EC 6.4.1.2; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding
Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; multicellular organismal protein metabolic process; tissue homeostasis; positive regulation of cellular metabolic process; energy reserve metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; carnitine shuttle; cellular lipid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process; biotin metabolic process; protein homotetramerization
Disease: Acetyl-coa Carboxylase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ACCalpha antibody
| Reference Product | PubMed Publications |
|---|---|
| PRKAA1 antibody | >2 publications with ACCalpha and PRKAA1 |
| PRKAA2 antibody | >1 publications with ACCalpha and PRKAA2 |
Pathways associated with anti-ACCalpha antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| AMPK Signaling Pathway antibodies | AMPK Signaling Pathway Diagram |
| Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies | Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram |
| ChREBP Activates Metabolic Gene Expression Pathway antibodies | ChREBP Activates Metabolic Gene Expression Pathway Diagram |
| Fatty Acid Biosynthesis Pathway antibodies | Fatty Acid Biosynthesis Pathway Diagram |
| Fatty Acyl-CoA Biosynthesis Pathway antibodies | Fatty Acyl-CoA Biosynthesis Pathway Diagram |
| Fatty Acid Biosynthesis Pathway antibodies | Fatty Acid Biosynthesis Pathway Diagram |
| Fatty Acid Biosynthesis Pathway antibodies | Fatty Acid Biosynthesis Pathway Diagram |
| Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies | Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram |
| Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway antibodies | Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway Diagram |
| Insulin Signaling Pathway antibodies | Insulin Signaling Pathway Diagram |
Diseases associated with anti-ACCalpha antibody
| Disease Name | Pubmed Publications |
|---|---|
| Fatty Liver Antibodies | >15 publications with ACCalpha and Fatty Liver |
| Neoplasms Antibodies | >6 publications with ACCalpha and Neoplasms |
| Obesity Antibodies | >6 publications with ACCalpha and Obesity |
| Liver Diseases Antibodies | >4 publications with ACCalpha and Liver Diseases |
| Insulin Resistance Antibodies | >3 publications with ACCalpha and Insulin Resistance |
| Inflammation Antibodies | >3 publications with ACCalpha and Inflammation |
| Hypertriglyceridemia Antibodies | >2 publications with ACCalpha and Hypertriglyceridemia |
| Weight Gain Antibodies | >2 publications with ACCalpha and Weight Gain |
| Hypercholesterolemia Antibodies | >1 publications with ACCalpha and Hypercholesterolemia |
| Hyperlipidemias Antibodies | >1 publications with ACCalpha and Hyperlipidemias |
Organs/Tissues associated with anti-ACCalpha antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Adipose Tissue Antibodies | >21 publications with ACCalpha and Adipose Tissue |
| Liver Antibodies | >19 publications with ACCalpha and Liver |
| Mammary Gland Antibodies | >16 publications with ACCalpha and Mammary Gland |
| Muscle Antibodies | >14 publications with ACCalpha and Muscle |
| Blood Antibodies | >11 publications with ACCalpha and Blood |
| Connective Tissue Antibodies | >9 publications with ACCalpha and Connective Tissue |
| Vascular Antibodies | >4 publications with ACCalpha and Vascular |
| Brain Antibodies | >4 publications with ACCalpha and Brain |
| Thyroid Antibodies | >3 publications with ACCalpha and Thyroid |
| Pancreas Antibodies | >3 publications with ACCalpha and Pancreas |