ACCN2 Antibody - C-terminal region
Référence OAAB05862
Conditionnement : 400ul
Marque : Aviva Systems Biology
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ACCN2 Antibody - C-terminal region (OAAB05862)
| Datasheets/Manuals | Printable datasheet for ACCN2 Antibody - C-terminal region (OAAB05862) |
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| Predicted Species Reactivity | Chicken|Human|Mouse|Rat |
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| Product Format | Liquid. PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | FC,IHC-P,WB |
| Additional Information | Function: Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Cellular Location Cell membrane; Multi- pass membrane protein Note=Localizes in synaptosomes at dendritic synapses of neurons Colocalizes with DLG4 (By similarity). Tissue Location Expressed in most or all neurons. |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This ACCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-526 amino acids from the C-terminal region of human ACCN2. |
| Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Predicted Homology Based on Immunogen Sequence | Chicken, Mouse, Rat |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Intended Use | ACCN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Application Info | WB: 1:1000 IHC-P: 1:50~100 FC: 1:10~50 |
| Other Applications Image 1 Data | ACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
| Gene Symbol | Asic1|ASIC1 |
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| Gene Full Name | acid sensing ion channel subunit 1|acid-sensing (proton-gated) ion channel 1 |
| Alias Symbols | A, Acc, ACCN2, acid sensing (proton gated) ion channel 1, acid-sensing (proton-gated) ion channel 1, Acid-sensing ion channel, acid-sensing ion channel 1, acid-sensing ion channel 1a protein, AI843610, amiloride-sensitive cation channel 2, neuronal, AS, ASIC, ASIC1a, B530003N02Rik, BNa, BNaC2, brain sodium channel 2, Cation channel, amiloride-sensitive, neuronal, 2, degenerin 2, proton gated cation channel ASIC1. |
| NCBI Gene Id | 11419|41|426883|79123 |
| Protein Name | Acid-sensing ion channel 1|acid-sensing ion channel 1 isoform a [Homo sapiens]|acid-sensing ion channel 1 isoform b [Homo sapiens]|acid-sensing ion channel 1 isoform c [Homo sapiens] |
| Description of Target | Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.|Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.|Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties.|Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. |
| Uniprot ID | P55926|P78348|Q1XA76|Q6NXK8 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_001086.2,NP_001243759.1,NP_064423.2 |
| Molecular Weight | 59909 |