Actin, Smooth Muscle (ACTA2, Actin Alpha 2 Smooth Muscle Aorta, Actin Aortic Smooth Muscle, Actin Vascular Smooth Muscle, ACTSA, ACTVS, Alpha 2 Actin, Alpha Actin 2, Alpha Cardiac Actin, Alpha Smooth Muscle, Alpha-actin-2, Aortic Smooth Muscle, ASMA, Cell
Référence MBS6123854-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Formalin-paraffin leiomyosarcoma stained with Smooth Muscle Actin MAb (SPM332).
ACTSA Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6123854MBS6123854 is an antibody targeting ACTSA. Also known as Actin, Smooth Muscle (ACTA2, Actin Alpha 2 Smooth Muscle Aorta, Actin Aortic Smooth Muscle, Actin Vascular Smooth Muscle, ACTSA, ACTVS, Alpha 2 Actin, Alpha Actin 2, Alpha Cardiac Actin, Alpha Smooth… More details
Product Overview
Online Datasheet in PDFProduct Name
Actin (ACTSA), Monoclonal Antibody
Full Product Name
Actin, Smooth Muscle (ACTA2, Actin Alpha 2 Smooth Muscle Aorta, Actin Aortic Smooth Muscle, Actin Vascular Smooth Muscle, ACTSA, ACTVS, Alpha 2 Actin, Alpha Actin 2, Alpha Cardiac Actin, Alpha Smooth Muscle, Alpha-actin-2, Aortic Smooth Muscle, ASMA, Cell
Product Gene Name
anti-ACTSA antibody
Product Synonym Names
ACTA2; Actin Alpha 2 Smooth Muscle Aorta; Actin Aortic Smooth Muscle; Actin Vascular Smooth Muscle; ACTSA; ACTVS; Alpha 2 Actin; Alpha Actin 2; Alpha Cardiac Actin; Alpha Smooth Muscle; Alpha-actin-2; Aortic Smooth Muscle; ASMA; Cell Growth-inhibiting Gene 46 Protein; Growth Inhibiting Gene 46
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
SPM332
Host
Mouse
Species Reactivity
Bovine, Canine, Chicken, Feline, Goat, Guinea Pig, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with horseradish peroxidase (HRP).
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes Actin, Smooth Muscle. Species Crossreactivity: Human, Baboon, Monkey, Bovine, Porcine, Sheep, Goat, Feline, Canine, Rabbit, Mouse, Rat, Guinea pig and Chicken. Others-not known.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,009 Da
OMIM
102620
Immunogen
N-Terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH. Cellular Localization: Cytoplasmic
Conjugate
HRP
Positive Control
Blood vessels in all tissues, smooth muscle or leiomyosarcoma
Product Categories/Family for anti-ACTSA antibody
Antibodies; Actin Related Proteins
Applications Tested/Suitable for anti-ACTSA antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-ACTSA antibody
WB: 0.5-1ug/ml
IP: 0.5-1ug/500ug protein lysate
IHC: 0.5-1ug/ml for 30 minutes at RT
Applications are based on unconjugated antibody.
IP: 0.5-1ug/500ug protein lysate
IHC: 0.5-1ug/ml for 30 minutes at RT
Applications are based on unconjugated antibody.
Product References and Citations for anti-ACTSA antibody
1. Skalli O et. al. Journal of Cell Biology, 1986, 103:2787-96.
Other Notes
Small volumes of anti-ACTSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ACTSA. It may not necessarily be applicable to this product.
NCBI Official Full Name
actin, alpha 2, smooth muscle, aorta, isoform CRA_a
NCBI Official Synonym Full Names
actin, alpha 2, smooth muscle, aorta
NCBI Official Symbol
ACTA2
NCBI Official Synonym Symbols
AAT6; ACTSA; MYMY5
UniProt Protein Name
Actin, aortic smooth muscle
UniProt Synonym Protein Names
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
Protein Family
Actin
UniProt Gene Name
ACTA2
UniProt Synonym Gene Names
ACTSA; ACTVS
UniProt Entry Name
ACTA_HUMAN
NCBI Protein Information
actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
NCBI Summary for ACTSA
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Show more UniProt Comments for ACTSA
ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.
Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton
Molecular Function: protein kinase binding; ATP binding
Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction
Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6
Show more Protein type: Contractile; Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton
Molecular Function: protein kinase binding; ATP binding
Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction
Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ACTSA antibody
| Reference Product | PubMed Publications |
|---|---|
| TGFB1 antibody | >141 publications with ACTSA and TGFB1 |
| MYH11 antibody | >26 publications with ACTSA and MYH11 |
| TAGLN antibody | >10 publications with ACTSA and TAGLN |
| CFL1 antibody | >1 publications with ACTSA and CFL1 |
| UBC antibody | >1 publications with ACTSA and UBC |
| ACTN2 antibody | >1 publications with ACTSA and ACTN2 |
Pathways associated with anti-ACTSA antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Muscle Contraction Pathway antibodies | Muscle Contraction Pathway Diagram |
| Myometrial Relaxation And Contraction Pathways antibodies | Myometrial Relaxation And Contraction Pathways Diagram |
| Smooth Muscle Contraction Pathway antibodies | Smooth Muscle Contraction Pathway Diagram |
| Striated Muscle Contraction Pathway antibodies | Striated Muscle Contraction Pathway Diagram |
| Vascular Smooth Muscle Contraction Pathway antibodies | Vascular Smooth Muscle Contraction Pathway Diagram |
| Vascular Smooth Muscle Contraction Pathway antibodies | Vascular Smooth Muscle Contraction Pathway Diagram |
Diseases associated with anti-ACTSA antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >222 publications with ACTSA and Neoplasms |
| Fibrosis Antibodies | >217 publications with ACTSA and Fibrosis |
| Inflammation Antibodies | >66 publications with ACTSA and Inflammation |
| Liver Diseases Antibodies | >65 publications with ACTSA and Liver Diseases |
| Disease Models, Animal Antibodies | >57 publications with ACTSA and Disease Models, Animal |
| Liver Cirrhosis Antibodies | >48 publications with ACTSA and Liver Cirrhosis |
| Kidney Diseases Antibodies | >41 publications with ACTSA and Kidney Diseases |
| Breast Neoplasms Antibodies | >33 publications with ACTSA and Breast Neoplasms |
| Aortic Aneurysm, Thoracic Antibodies | >29 publications with ACTSA and Aortic Aneurysm, Thoracic |
| Heart Diseases Antibodies | >27 publications with ACTSA and Heart Diseases |
Organs/Tissues associated with anti-ACTSA antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Muscle Antibodies | >569 publications with ACTSA and Muscle |
| Vascular Antibodies | >173 publications with ACTSA and Vascular |
| Blood Antibodies | >126 publications with ACTSA and Blood |
| Eye Antibodies | >99 publications with ACTSA and Eye |
| Lung Antibodies | >99 publications with ACTSA and Lung |
| Connective Tissue Antibodies | >89 publications with ACTSA and Connective Tissue |
| Liver Antibodies | >85 publications with ACTSA and Liver |
| Kidney Antibodies | >71 publications with ACTSA and Kidney |
| Skin Antibodies | >63 publications with ACTSA and Skin |
| Embryonic Tissue Antibodies | >47 publications with ACTSA and Embryonic Tissue |