ACVR1 Antibody - N-terminal region
Référence ARP45040_P050-25UL
Conditionnement : 25ul
Marque : Aviva Systems Biology
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
ACVR1 Antibody - N-terminal region (ARP45040_P050)
| Datasheets/Manuals | Printable datasheet for anti-ACVR1 (ARP45040_P050) antibody |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | IHC, WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 93%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93% |
| Peptide Sequence | Synthetic peptide located within the following region: TCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIIL |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-ACVR1 (ARP45040_P050) antibody is Catalog # AAP45040 (Previous Catalog # AAPP12328) |
| Enhanced Validation | Relative Expression (Western Blot)  |
| Reference | Casagrandi,D., (2003) Mol. Hum. Reprod. 9 (4), 199-203 |
|---|---|
| Gene Symbol | ACVR1 |
| Gene Full Name | Activin A receptor, type I |
| Alias Symbols | FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2 |
| NCBI Gene Id | 90 |
| Protein Name | Activin receptor type-1 |
| Description of Target | Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. |
| Uniprot ID | Q04771 |
| Protein Accession # | NP_001096 |
| Nucleotide Accession # | NM_001105 |
| Protein Size (# AA) | 509 |
| Molecular Weight | 57 kDa |
| Protein Interactions | UBC; USP15; BMPR1A; ACVR1; INHBA; ACVR2A; PEG10; SMAD6; SMAD7; BAMBI; SMURF1; IGSF1; TSC22D1; TGFBR1; DCAF6; FGD6; FCHO1; PLEK; TTC17; RHEBL1; WDR61; RASL12; RASD2; PLEKHJ1; CDK14; NEK8; DUSP13; NUAK2; FKBP4; RAB6B; RAB17; UBXN1; FBXO30; RHOJ; PLEKHB1; UB |
