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> Aggrecan (ACAN) Rabbit Polyclonal Antibody

Aggrecan (ACAN) Rabbit Polyclonal Antibody

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Référence TA336492

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Aggrecan (ACAN) Rabbit Polyclonal Antibody

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SKU
TA336492
Rabbit Polyclonal Aggrecan Neoepitope Antibody
Size:
100 ul
Conjugation:
Unconjugated
 

View other "Aggrecan or NM_001135" antibodies

Specifications
Product Data
Application FC, ICC/IF, IHC, WB
Recommended Dilution Immunohistochemistry-Frozen, Flow Cytometry, Immunohistochemistry-Paraffin: 1:1000, Immunohistochemistry: 1:1000, Immunocytochemistry/ Immunofluorescence: 1:20-1:100, Western Blot: 1:1000
Reactivity Bovine, Canine, Human, Mouse, Porcine, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to a region of human Aggrecan (within residues 350-400). UniProt# P16112
Buffer PBS, 30% glycerol, 0.1% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 61 kDa
Gene Name aggrecan
Database Link
Background Aggrecan Neoepitope (ACAN) is a proteoglycan belonging to aggrecan/versican proteoglycan family and is a major component of extracellular matrix of cartilagenous tissues. ACAN proteoglycan is mainly consists of chondroitin sulfate, however, it also contains keratan sulfate chains, N/O-linked oligosaccharides. Aggrecanase mediated cleavage results in ACAN fragments release from articular cartilage into synovial fluid during different stages of human osteoarthritis. ACAN is a secreted protein found in extracellular space/extracellular matrix and is more or less restricted to cartilages where it interact with FBLN1 as well as COM for serving the role of resisting compression in cartilage. ACAN binds to hyaluronic acid via an N-terminal globular region with high avidity and its expression occurs in chondrocytes throughout the developing skeleton. ACAN defects have been linked to spondyloepiphyseal dysplasia type Kimberley (SEDK), spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN), osteochondritis dissecans short stature and early-onset osteoarthritis (OD).
Synonyms AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
Note This Aggrecan Neoepitope antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-paraffin embedded sections, and Western Blot. In WB a band is detected at ~61 kDa representing the neoepitope sequence (NITEGE) generated by aggrecanase-mediated cleavage at Glu373-Ala374 of aggrecan core proteins. Use in Immunohistochemistry-Frozen and Flow Cytometry reported in scientific literature (PMID 21482542)
Reference Data
Protein Categories Intracellular Proteins, Secreated Proteins
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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