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> alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: C2]

alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: C2]

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Référence AM32231PU-N

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alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: C2]

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SKU
AM32231PU-N
alpha 1 Fetoprotein (AFP) mouse monoclonal antibody, clone C2, Purified
Size:
100 ug
Conjugation:
Unconjugated
 

View other "AFP or NP_001125.1" antibodies

Specifications
Product Data
Clone Name C2
Application ELISA, IHC
Recommended Dilution ELISA. 
Immunohistochemistry on Cryostat Sections and cell smears.
Immunohistochemistry on Formalin Fixed, Paraffin Embedded Sections.
Reactivity Human, Mouse
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen A BALB/c mouse has been immunized with Alpha Fetoprotein isolated from serum of hepatoma patients.
Splenocytes were fused with mouse myeloma cell line P3-X63-Ag8.653.
Specificity C2 is characterized in the ISOBM TD-2 workshop and assigned by K. Nustad to group E of a cluster of 6 major epitopes of Human Alpha Fetoprotein. 
C2 specifically reacts with Human and Mouse AFP, but does not react with Rat, Dog or calf Alpha Fetoprotein as demonstrated by ELISA.
Buffer PBS
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.02% Sodium Azide
Concentration lot specific
Conjugation Unconjugated
Storage Store undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name alpha fetoprotein
Database Link
Background Human alpha fetoprotein is an oncofetal protein of 70 kD. Its gene is cloned and sequenced and its structure identified. AFP is expressed in fetal liver and is normally absent in healthy adult tissues. It is expressed in all yolk sac tumors, in some germ cell tumors and in hepatocellular carcinomas. 
Alpha Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. alpha Fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha Fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha Fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha Fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha Fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Synonyms Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP
Reference Data
Protein Categories Secreated Proteins
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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