Alpha Synuclein Antibody: PerCP
Référence MBS8002063-5x0,1mg
Conditionnement : 5x0.1mg
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Western blot analysis of Mouse Brain showing detection of ~14.46kDa Alpha Synuclein protein using Rabbit Anti-Alpha Synuclein Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Mouse Brain. Load: 15 ug. Block: 5% Skim Milk powder in TBST. Primary Antibody: Rabbit Anti-Alpha Synuclein Polyclonal Antibody at 1:1000 for 2 hours at RT with shaking. Secondary Antibody: Goat anti-rabbit IgG:HRP at 1:4000 for 1 hour at RT with shaking. Color Development: Chemiluminescent for HRP (Moss) for 5 min in RT. Predicted/Observed Size: ~14.46kDa. Other Band(s): Higher molecular weight oligomers.
Alpha Synuclein (SNCA) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8002063Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally,… More details
Product Overview
Online Datasheet in PDFProduct Name
Alpha Synuclein (SNCA), Polyclonal Antibody
Full Product Name
Alpha Synuclein Antibody: PerCP
Product Gene Name
anti-SNCA antibody
Product Synonym Names
Rabbit Anti-Human Alpha Synuclein Polyclonal; Alpha Synuclein Antibody; Non-A4 component of amyloid precursor Antibody; MGC105443 Antibody; OTTHUMP00000218552 Antibody; MGC110988 Antibody; OTTHUMP00000218553 Antibody; Synuclein alpha 140 Antibody; alphaSYN Antibody; Parkinson disease familial 1 Antibody; OTTHUMP00000218554 Antibody; Parkinson disease (autosomal dominant; Lewy body) 4 Antibody; Synuclein; alpha (non A4 component of amyloid precursor) Antibody; OTTHUMP00000218549 Antibody; Non A4 component of amyloid precursor Antibody; MGC127560 Antibody; SYN Antibody; SNCA Antibody; MGC64356 Antibody; Non A4 component of amyloid Antibody; PARK4 Antibody; Alpha synuclein Antibody; PARK 1 Antibody; Snca synuclein; Synuclein alpha Antibody; Non-A4 component of amyloid; precursor of Antibody; OTTHUMP00000218551 Antibody; PARK 4 Antibody; PARK1 Antibody; Alpha-synuclein; isoform NACP140 Antibody; Non-A-beta component of alzheimers disease amyloid; Non-A beta component of AD amyloid Antibody; NACP Antibody; SYUA_HUMAN Antibody; Alpha-synuclein Antibody; Non A beta component of AD amyloid Antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Purity/Purification
Protein A Purified
Concentration
1 mg/ml (lot specific)
Specificity
Detects ~14.46kda. Highly expressed in brain (presynaptic nerve terminals) but is also expressed in low concentrations in all tissues examined except in liver.
Preparation and Storage
Store at-20 degree C.
Matching Pairs
Unconjugated Antibody: N/A (MBS8002063)
PerCP Conjugated Antibody: Alpha Synuclein (MBS8002063)
PerCP Conjugated Antibody: Alpha Synuclein (MBS8002063)
Immunogen
Synthetic peptide from the full length of Human Alpha Synuclein
Immunogen Species
Human
Conjugate
PerCP
Cellular Localization
Cytoplasm, Membrane, Nucleus, Cell Junction, Synapse, Secreted
Certificate of Analysis
A 1:1000 dilution was sufficient for detection of Alpha Synuclein in 15 mug of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Product Categories/Family for anti-SNCA antibody
Neuroscience; Neurodegeneration; Alzheimer's Disease; Tangles & Tau; Neuroscience; Neurodegeneration; Parkinson's Disease; Synuclein
Applications Tested/Suitable for anti-SNCA antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SNCA antibody
WB: 1:1000
Western Blot (WB) of anti-SNCA antibody
Western blot analysis of Mouse Brain showing detection of ~14.46kDa Alpha Synuclein protein using Rabbit Anti-Alpha Synuclein Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Mouse Brain. Load: 15 ug. Block: 5% Skim Milk powder in TBST. Primary Antibody: Rabbit Anti-Alpha Synuclein Polyclonal Antibody at 1:1000 for 2 hours at RT with shaking. Secondary Antibody: Goat anti-rabbit IgG:HRP at 1:4000 for 1 hour at RT with shaking. Color Development: Chemiluminescent for HRP (Moss) for 5 min in RT. Predicted/Observed Size: ~14.46kDa. Other Band(s): Higher molecular weight oligomers.
Product References and Citations for anti-SNCA antibody
1. "Genetics Home Reference: SNCA". US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
Other Notes
Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for SNCA purchase
MBS8002063 is an antibody targeting SNCA. Also known as Alpha Synuclein Antibody: PerCP. Reactive in Human, Mouse, Rat. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein alpha
NCBI Official Symbol
SNCA
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
Protein Family
Alpha-synuclein
NCBI Protein Information
alpha-synuclein
NCBI Summary for SNCA
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-SNCA antibody
| Reference Product | PubMed Publications |
|---|---|
| SNCB antibody | >74 publications with SNCA and SNCB |
| MAPT antibody | >64 publications with SNCA and MAPT |
| SNCAIP antibody | >31 publications with SNCA and SNCAIP |
| PARK2 antibody | >30 publications with SNCA and PARK2 |
| APP antibody | >16 publications with SNCA and APP |
| SLC6A3 antibody | >12 publications with SNCA and SLC6A3 |
| MAPK1 antibody | >5 publications with SNCA and MAPK1 |
| TOR1A antibody | >4 publications with SNCA and TOR1A |
| BAD antibody | >3 publications with SNCA and BAD |
| SQSTM1 antibody | >3 publications with SNCA and SQSTM1 |
Pathways associated with anti-SNCA antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Alpha-synuclein Signaling Pathway antibodies | Alpha-synuclein Signaling Pathway Diagram |
| Alzheimer's Disease Pathway antibodies | Alzheimer's Disease Pathway Diagram |
| Alzheimer's Disease Pathway antibodies | Alzheimer's Disease Pathway Diagram |
| Alzheimers Disease Pathway antibodies | Alzheimers Disease Pathway Diagram |
| Amyloids Pathway antibodies | Amyloids Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| EGFR1 Signaling Pathway antibodies | EGFR1 Signaling Pathway Diagram |
| Parkin-Ubiquitin Proteasomal System Pathway antibodies | Parkin-Ubiquitin Proteasomal System Pathway Diagram |
| Parkinson's Disease Pathway antibodies | Parkinson's Disease Pathway Diagram |
| Parkinsons Disease Pathway antibodies | Parkinsons Disease Pathway Diagram |
Diseases associated with anti-SNCA antibody
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >1049 publications with SNCA and Nervous System Diseases |
| Brain Diseases Antibodies | >1028 publications with SNCA and Brain Diseases |
| Neurodegenerative Diseases Antibodies | >1016 publications with SNCA and Neurodegenerative Diseases |
| Movement Disorders Antibodies | >896 publications with SNCA and Movement Disorders |
| Parkinsonian Disorders Antibodies | >829 publications with SNCA and Parkinsonian Disorders |
| Parkinson Disease Antibodies | >755 publications with SNCA and Parkinson Disease |
| Lewy Body Disease Antibodies | >270 publications with SNCA and Lewy Body Disease |
| Nerve Degeneration Antibodies | >160 publications with SNCA and Nerve Degeneration |
| Disease Models, Animal Antibodies | >127 publications with SNCA and Disease Models, Animal |
| Drug Toxicity Antibodies | >71 publications with SNCA and Drug Toxicity |
Organs/Tissues associated with anti-SNCA antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Nerve Antibodies | >986 publications with SNCA and Nerve |
| Brain Antibodies | >718 publications with SNCA and Brain |
| Blood Antibodies | >53 publications with SNCA and Blood |
| Embryonic Tissue Antibodies | >28 publications with SNCA and Embryonic Tissue |
| Kidney Antibodies | >19 publications with SNCA and Kidney |
| Heart Antibodies | >9 publications with SNCA and Heart |
| Eye Antibodies | >8 publications with SNCA and Eye |
| Skin Antibodies | >6 publications with SNCA and Skin |
| Bone Antibodies | >6 publications with SNCA and Bone |
| Liver Antibodies | >6 publications with SNCA and Liver |