Amyloid Oligomers (A11) Antibody
Référence OASE00468-100UL-HRP
Conditionnement : 100ul
Marque : Aviva Systems Biology
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Amyloid Oligomers (A11) Antibody (OASE00468)
| Datasheets/Manuals | Printable datasheet for Amyloid Oligomers (A11) Antibody (OASE00468) |
|---|---|
| COA Datasheet | A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. |
| Predicted Species Reactivity | Eukaryote|Human|Mouse|Rat |
|---|---|
| Product Format | Liquid. PBS, 50% glycerol, 0.09% sodium azide |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | DB,ELISA,ICC,IF,IHC,IP,WB |
| Additional Information | Cellular Localization: Membrane Certificate of Analysis: A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 ug of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. |
| Reconstitution and Storage | -20°C |
| Immunogen | Synthetic molecular mimic of soluble human amyloid beta oligomers |
| Purification | Protein A Purified |
| Concentration | Varies by lot. See vial for concentration. |
| Specificity | Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils. |
| Application Info | The suggested dilution for the current lot of OASE00468 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user. |
| Storage Buffer | PBS, 50% glycerol, 0.09% sodium azide |
| Gene Symbol | APP|EIF3G |
|---|---|
| Gene Full Name | amyloid beta precursor protein|eukaryotic translation initiation factor 3 subunit G |
| Alias Symbols | AAA, ABETA, ABPP, AD1, alpha-sAPP, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, amyloid precursor protein, amyloid-beta precursor protein, APPI, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, CTFgamma, CVAP, eIF3-delta, EIF3-P42, eIF3-p44, EIF3S4, eukaryotic translation initiation factor 3 RNA-binding subunit, eukaryotic translation initiation factor 3 subunit G, eukaryotic translation initiation factor 3 subunit p42, eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa, peptidase nexin-II, PN-II, PN2, preA4, protease nexin-II, testicular tissue protein Li 2. |
| NCBI Gene Id | 351|8666 |
| Protein Name | Amyloid-beta A4 protein|Homo sapiens amyloid beta precursor protein (APP), transcript variant 1, mRNA |
| Description of Target | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. |
| Uniprot ID | P05067 |
| Nucleotide Accession # | https://www.ncbi.nlm.nih.gov/nuccore/NM_000484.2 |
