Specifications

Product Data
Applications	ELISA, IHC, WB
Recommended Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 0.5 - 2 µg/ml.
Reactivities	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ACE2 antibody was raised against synthetic peptide
Specificity	This antibody reacts to Angiotensin I Converting Enzyme 2 (ACE2).
Formulation	PBS containing 0.02% sodium azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage	Store the antibody undiluted at 2-8°C.
Stability	Shelf life: one year from despatch.
Gene Name	Homo sapiens angiotensin I converting enzyme 2 (ACE2)
Database Link	Entrez Gene 59272 Human UniProt ID Q9BYF1
Background	Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Synonyms	Angiotensin-converting enzyme 2
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Renin-angiotensin system