General Information
| Short Description | Mouse monoclonal anti-Low affinity immunoglobulin gamma Fc region receptor II-b for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IV-3 |
| Isotype | IgG2bk |
| Conjugation | AF647 |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID |
Additional Info
| Tissue Specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-BIgg Fc Receptor Ii-BCdw32Fc-Gamma Rii-BFc-Gamma-RiibFcrii-BCd Antigen Cd32 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B antibodyAnti-Igg Fc Receptor Ii-B antibodyAnti-Cdw32 antibodyAnti-Fc-Gamma Rii-B antibodyAnti-Fc-Gamma-Riib antibodyAnti-Fcrii-B antibodyAnti-Cd Antigen Cd32 antibodyAnti-FCGR2B antibodyAnti-CD32 antibodyAnti-FCG2 antibodyAnti-IGFR2 antibody |
Information sourced from Uniprot.org