Anti-CD52 [YTH 34.5-G2b (Campath-1G)]

Référence MBS488135-0,2mg

Conditionnement : 0.2mg

Marque : MyBiosource

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CD52 Recombinant Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS488135

Recombinant monoclonal antibody to CD52. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the hybridoma YTH 34.5-G2b (Campath-1G). More details

Product Overview

Online Datasheet in PDF
Product Name
CD52, Recombinant Antibody
Full Product Name
Anti-CD52 [YTH 34.5-G2b (Campath-1G)]
Product Gene Name
CD52 recombinant antibody
Product Synonym Names
CDw52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5
Isotype
Rat IgG2b, kappa
Clone Number
YTH 34.5-G2b (Campath-1G)
Species Reactivity
Human, Rhesus Monkey
Purity/Purification
Protein A Affinity Purified
Specificity
Human CD52 antigen, also known as CAMPATH-1. CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable.
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Molecular Weight
6,614 Da
OMIM
X62466 mRNA
3D Structure
ModBase 3D Structure for P31358
Animal-free Manufacturing Platform
The recombinant antibody is manufactured using a recombinant, mammalian HEK293-based expression platform. The manufacturing platform is animal-free and animal component-free.
Buffer Composition
PBS only with 0.02% Proclin 300.
Immunogen
Human peripheral mononuclear cells enriched for T-cells.

Product Categories/Family for CD52 recombinant antibody

Invivo; Biotherapeutics; Biosimilar
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for CD52 recombinant antibody
Cytotoxicity Assay, ELISA (EIA), Immunohistochemistry (IHC) Formalin/Paraffin, In Vivo, Flow Cytometry (FC/FACS), Western Blot (WB)

Western Blot (WB) of CD52 recombinant antibody

Western Blot using anti-CD52 antibody YTH 34.5-G2b (Campath-1G) Mouse spleen samples were resolved on a 15% SDS PAGE gel and blots probed with the rat IgG1-chimeric version of YTH 34.5-G2b at 1.5 ug/ml before detection using an anti-rat secondary antibody. Protein was detected by chemiluminescence. The expected unmodified running size for CD52 is ~8kDa, but this protein is extensively glycosylated and exhibits running sizes of ~11-25kDa. successfully detected CD52 in mouse spleen samples.
Anti-CD52 Recombinant Antibody – Cat# MBS488135

Product References and Citations for CD52 recombinant antibody

Hale G et al. Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 1983 Oct; 62(4):873-82. PMID:6349718

Other Notes

Small volumes of CD52 recombinant antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD52 purchase

MBS488135 is a recombinant antibody targeting CD52. Also known as Anti-CD52 [YTH 34.5-G2b (Campath-1G)]. Reactive in Human, Rhesus Monkey.

Additional Details

NCBI/Uniprot data below describe general gene information for CD52. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CAMPATH-1 antigen
NCBI Official Synonym Full Names
CD52 molecule
NCBI Official Symbol
CD52
NCBI Official Synonym Symbols
CDW52
UniProt Protein Name
CAMPATH-1 antigen
UniProt Synonym Protein Names
CDw52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; He5; CD_antigen: CD52
Protein Family
CAMPATH-1 antigen
UniProt Gene Name
CD52
UniProt Synonym Gene Names
CDW52; HE5; He5
UniProt Entry Name
CD52_HUMAN
NCBI Protein Information
CAMPATH-1 antigen

UniProt Comments for CD52

CD52: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Protein type: Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane; membrane

Biological Process: elevation of cytosolic calcium ion concentration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD52 recombinant antibody

 Reference Product  PubMed Publications
 CD4 recombinant antibody  >103 publications with CD52 and CD4
 CD19 recombinant antibody  >55 publications with CD52 and CD19
 CD22 recombinant antibody  >38 publications with CD52 and CD22
 CD5 recombinant antibody  >27 publications with CD52 and CD5
 CD7 recombinant antibody  >8 publications with CD52 and CD7
 NPC2 recombinant antibody  >5 publications with CD52 and NPC2
 CRISP1 recombinant antibody  >2 publications with CD52 and CRISP1
 GPR64 recombinant antibody  >2 publications with CD52 and GPR64

Pathways associated with CD52 recombinant antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with CD52 recombinant antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >44 publications with CD52 and Cardiovascular Diseases
 Thrombocytopenia Antibodies  >37 publications with CD52 and Thrombocytopenia
 Inflammation Antibodies  >34 publications with CD52 and Inflammation
 Necrosis Antibodies  >33 publications with CD52 and Necrosis
 Infertility, Male Antibodies  >19 publications with CD52 and Infertility, Male
 Lung Diseases Antibodies  >18 publications with CD52 and Lung Diseases
 Kidney Diseases Antibodies  >16 publications with CD52 and Kidney Diseases
 Disease Models, Animal Antibodies  >13 publications with CD52 and Disease Models, Animal
 Liver Diseases Antibodies  >12 publications with CD52 and Liver Diseases
 Neoplasms, Experimental Antibodies  >5 publications with CD52 and Neoplasms, Experimental

Organs/Tissues associated with CD52 recombinant antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >415 publications with CD52 and Blood
 Bone Marrow Antibodies  >146 publications with CD52 and Bone Marrow
 Kidney Antibodies  >67 publications with CD52 and Kidney
 Epididymis Antibodies  >37 publications with CD52 and Epididymis
 Lymph Node Antibodies  >24 publications with CD52 and Lymph Node
 Lymph Antibodies  >24 publications with CD52 and Lymph
 Lung Antibodies  >21 publications with CD52 and Lung
 Spleen Antibodies  >19 publications with CD52 and Spleen
 Heart Antibodies  >17 publications with CD52 and Heart
 Brain Antibodies  >17 publications with CD52 and Brain