Anti-CDH1/E-cadherin/CD324 Antibody
Référence T9901A-1434-1mg
Conditionnement : 1mg
Marque : TargetMol
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Anti-Human CDH1/E-cadherin/CD324 Antibody
Copy Product InfoAnti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Related Conjugates and Formulations
Antigen Details
Antibody Information
Storage & Solubility Information
| Description | Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis. |
| In vitro | In immunofluorescence studies, Anti-CDH1/E-cadherin/CD324 Antibody showed strong and specific reactivity with epithelial tissues, such as the lining of the intestine and kidney tubules, localizing primarily to the cell-cell interface of the plasma membrane [1]. |
| In vivo | In mouse embryo assays, the addition of Anti-CDH1/E-cadherin/CD324 Antibody (anti-uvomorulin) to 8-cell stage embryos caused complete decompaction within 2-4 hours, demonstrating that the antibody effectively disrupts the calcium-dependent cell-cell adhesion required for blastocyst formation [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | P12830 |
| Target | CDH1/E-cadherin/CD324 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |