DNMT3B pAb
Anti-DNMT3B Antibody
Anti-DNMT3B Antibody
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Product Description
Specifications
| Size | 20 µL, 100 µL |
| Species | Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q9UBC3 |
| Gene Id | 1789 |
| Gene Symbols | DNMT3B |
| Protein Name / Synonyms | DNMT3B, ICF, ICF1, M.HsaIIIB, DNA methyltransferase 3 beta |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Dilutions
WB 1:200 - 1:1000
Format
Calculated MW
77-95kDa
Observed MW
96kDa
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DNMT3B (NP_008823.1).
Modification
Unmodified
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.