Anti-FURIN Antibody (8Q583)
Référence NB-64-120159-100uL
Conditionnement : 100uL
Marque : Neo Biotech
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Anti-FURIN Antibody (8Q583)
(Synonyms: PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme) Copy Product InfoSynonyms: PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme
Catalog No. TMAH-00465 Copy Product Info
Anti-FURIN Antibody (8Q583) is an antibody targeting FURIN. Anti-FURIN Antibody (8Q583) can be used in ELISA,IHC,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-FURIN Antibody (8Q583) is an antibody targeting FURIN. Anti-FURIN Antibody (8Q583) can be used in ELISA,IHC,WB. |
| Synonyms | PCSK3, Paired basic amino acid residue-cleaving enzyme, PACE, FURIN, FUR, Dibasic-processing enzyme |
| Ig Type | Rabbit IgG |
| Clone | 8Q583 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate, HT-29 whole cell lysate, HepG2 whole cell lysate, U-87 whole cell lysate -All lanes: Furin antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 87 kDa -Observed band size: 87, 72 kDa 2. IHC image of TMAH-00465 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA IHC WB |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Secreted. Endosome membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Seems to be expressed ubiquitously. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). (Microbial infection) Cleaves and activates diphtheria toxin DT. (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA). (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Furin |
| Antigen Species | Human |
| Gene Name | FURIN |
| Gene ID | 5045 |
| Uniprot ID | P09958 |
| Biology Area | Cell biology, Metabolism, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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