Anti-IL-10 Antibody (9H714)
Référence NB-64-120302-50uL
Conditionnement : 50uL
Marque : Neo Biotech
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Anti-IL-10 Antibody (9H714)
(Synonyms: TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF) Copy Product InfoSynonyms: TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF
Catalog No. TMAH-00607 Copy Product Info
Anti-IL-10 Antibody (9H714) is an antibody targeting IL-10. Anti-IL-10 Antibody (9H714) can be used in ELISA,IHC.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-IL-10 Antibody (9H714) is an antibody targeting IL-10. Anti-IL-10 Antibody (9H714) can be used in ELISA,IHC. |
| Synonyms | TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF |
| Ig Type | hIgG1 |
| Clone | 9H714 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00607 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL10 Protein |
| Antigen Species | Human |
| Gene Name | IL10 |
| Gene ID | 3586 |
| Uniprot ID | P22301 |
| Biology Area | Cancer, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Keywords
MGC-126451MGC-126450MGC 126451MGC 126450IL10IL 10
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Related Tags: Anti-IL-10 Antibody (9H714) chemical structure
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