General Information
| Short Description | Rabbit polyclonal KIR2DL4 (22-242) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen Region | 22-242 |
| Immunogen Sequence | WAHVGGQDKPFCSAWPSAVV PQGGHVTLRCHYRRGFNIFT LYKKDGVPVPELYNRIFWNS FLISPVTPAHAGTYRCRGFH PHSPTEWSAPSNPLVIMVTG LYEKPSLTARPGPTVRAGEN VTLSCSSQSSFDIYHLSREG EAHELRLPAVPSINGTFQAD FPLGPATHGETYRCFGSFHG SPYEWSDPSDPLPVSVTGNP SSSWPSPTEPSFKTGIARHL H |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human KIR2DL4 (NP_002246.5). |
Additional Info
| Tissue Specificity | Expressed in decidual NK cells and innate lymphoid cell type I (ILC1). Expressed in a subset of peripheral NK cells. |
| Function | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl4Cd158 Antigen-Like Family Member DG9pKiller Cell Inhibitory Receptor 103asKir-103asMhc Class I Nk Cell Receptor Kir103asCd Antigen Cd158d |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Killer Cell Immunoglobulin-Like Receptor 2dl4 antibodyAnti-Cd158 Antigen-Like Family Member D antibodyAnti-G9p antibodyAnti-Killer Cell Inhibitory Receptor 103as antibodyAnti-Kir-103as antibodyAnti-Mhc Class I Nk Cell Receptor Kir103as antibodyAnti-Cd Antigen Cd158d antibodyAnti-KIR2DL4 antibodyAnti-CD158D antibodyAnti-KIR103AS antibody |
Information sourced from Uniprot.org