Anti-Mouse CD278 (ICOS) [Clone 7E.17G9] - PE

Mouse ICOS cDNA and ICOS hexahistidine fusion protein

This Rphycoerythrin (RPE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This RPE conjugate is stable when stored at 28°C. Do not freeze.

Next Day 28°C

Blue Laser (488 nm) and/or Green Laser (532 nm)/YellowGreen Laser (561 nm)

Clone 7E.17G9 recognizes an epitope on mouse CD278.

CD278 (ICOS) belongs to the CD28 and CTLA4 cellsurface receptor family. It forms homodimers (4757kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, upregulation of molecules that mediate cellcell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.

B7h/B7RP1/GL50

1. Flavell, R. A. et al. (2001) Nature 409:97 2. Bachmann, M. F. et al. (2000) J. Exp. Med. 192:53 3. Kroczek, R. A. et al. (1999) Nature 397:263