Anti-Mouse CD54 (ICAM-1) [Clone YN1/1.7.4] - APC
Référence C2394-25
Conditionnement : 25ug
Marque : Leinco Technologies
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AntiMouse CD54 (ICAM1) [Clone YN1/1.7.4] — APC
AntiMouse CD54 (ICAM1) [Clone YN1/1.7.4] — APC
Product No.: C2394
Clone YN1/1.7.4 Target CD54 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Ly47, ICAM1 Isotype Rat IgG2b κ Applications FC |
Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.2 mg/ml Formulation This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This APC conjugate is stable when stored at 28°C. Do not freeze. Country of Origin USA Shipping Next Day 28°C Excitation Laser Red Laser (650 nm) RRIDAB_2829488 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this YN1/1.7.4 antibody for staining cells in flow cytometry is ≤ 0.06 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? B IHC (Frozen) For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone YN1/1.7.4 recognizes an epitope on mouse CD54. Background ICAM1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signaltransducing functions of ICAM1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies. Antigen Distribution CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. Ligand/Receptor CD11a/CD18 (LFA1) or CD11b/CD18 (Mac1) and CD11c/CD18, CD43, hyaluronan, fibrinogen PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Adhesion . Cell Biology . Costimulatory Molecules . Immunology . Innate Immunity . Neuroscience . Neuroscience Cell Markers . Stem Cell References & Citations1. Li, S. et al. (2009) Biochem. Biophys. Res. Commun. 381: 459 2. Wolf, S. et al. (2009) Pharmacol. Rep. 61: 22 3. Ozcan, U. et al. (2009) Arch Gynecol. Obstet. |