Anti-Mouse CD80 [Clone 16-10A1] - PE

Purified Recombinant Mouse CD80 (>98%)

This Rphycoerythrin (RPE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This Rphycoerythrin (RPE) conjugate is stable when stored at 28°C. Do not freeze.

Next Day 28°C

Blue Laser (488 nm) and/or Green Laser (532 nm)/YellowGreen Laser (561 nm)

Clone 1610A1 recognizes an epitope on mouse CD80.

CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B72) to prime T cells. CD80 binds to CTLA4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs costimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cellmediated cell death of the CD80 carrier. The activation of Natural Killer cellmediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.

CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells.

CD28 (stimulatory), CD152(CTLA4) (inhibitory)