Anti-Mouse/Rat CD90.1 (Thy-1.1) [Clone OX-7] - APC
Référence C874-100
Conditionnement : 100ug
Marque : Leinco Technologies
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AntiMouse/Rat CD90.1 (Thy1.1) [Clone OX7] — APC
AntiMouse/Rat CD90.1 (Thy1.1) [Clone OX7] — APC
Product No.: C874
Clone OX7 Target CD90.1 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD90, CD90.1, Thy1, Thy1.1, Thy1.2, Thy1.2 Isotype Mouse IgG1 κ Applications FC |
Antibody DetailsProduct DetailsReactive Species Mouse ⋅ Rat Host Species Mouse Product Concentration 0.2 mg/ml Formulation This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This Allophycocyanin (APC) conjugate is stable when stored at 28°C. Do not freeze. Country of Origin USA Shipping Next Day 28°C Excitation Laser Red Laser (650 nm) Additional Applications Reported In Literature ? FC IF IHC Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone OX7 activity is directed against both rat and murine CD90/Thy1. Background CD90/Thy1 (murine CD90.1/Thy1.1) is a cell surface glycoprotein that was the first protein of the immunoglobulin superfamily to be discovered5. The 25 kDa core protein is Nglycosylated at three sites, leading to isoforms with a range of molecular masses (2537 kDa). CD90 is composed of a single Vlike immunoglobulin domain anchored by a disulfide bond between Cys 28 and Cys 104. Despite its lack of an intracellular domain, CD90 is located in the outer leaflet of lipid rafts at the cell membrane, allowing signaling functions by cis and transinteractions with a variety of proteins, including G inhibitory proteins, the Src family kinase (SFK) members src and cfyn, and tubulin. CD90 has been found to play a role in numerous cellular activities, such as cell adhesion, apoptosis, metastasis, inflammation, and fibrosis. In mouse strains expressing CD90.1, it is expressed on earlystage hematopoietic cells in bone marrow, thymocytes, and circulating mature T cells. The OX7 antibody has been reported to induce leukocyte activation, glomerular nephritis, apoptosis in glomerular mesangial cells, and vascular permeability. CD90 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Diseases associated with CD90 dysfunction include nasopharyngeal carcinoma and thymoma. Antigen Distribution CD90 is present on a variety of cell types in murine and rat, including lymphatic vessels1, T cells2, neurons3 and fibroblasts4. NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Jurisic G, Iolyeva M, Proulx ST, et. al. Exp Cell Res. 316: 2982–2992. 2010. 2. Ledbetter JA, Rouse RV, Micklem HS, et. al. J Exp Med. 152: 280–295. 1980. 3. Schrader JW, Battye F, Scollay R. Proc Natl Acad Sci. U S A 79: 4161–4165. 1982. 4. Phipps RP, Baecher C, Frelinger JG, et. al. Eur J Immunol. 20: 1723–1727. 1990. 5. Hu P, Leyton L, Hagood JS, Barker TH. Front Cell Dev Biol. Jun 6;10:928510. 2022. 6. Crook K, Hunt SV. Dev Immunol. 4(4):23546. 1996. 7. Zhang J, Wang JH. Methods Mol Biol. 1842:217228. 2018 8. Hermans MH, Opstelten D. J Histochem Cytochem. Dec;39(12):162734. 1991 |