Anti-NCOR1 Mouse mAb
Référence MBS475850-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
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Immunohistochemistry of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right) using the antibody NCOR1 mouse mAb.
NCOR1 Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS475850Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligandindependent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It… More details
Product Overview
Online Datasheet in PDFProduct Name
NCOR1, Monoclonal Antibody
Full Product Name
Anti-NCOR1 Mouse mAb
Product Gene Name
anti-NCOR1 antibody
Product Synonym Gene Name
N-CoR; TRAC1; hN-CoR
Product Synonym Names
N-CoR; TRAC1; hN-CoR
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7A7A9
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid in Purified antibody in PBS with 0.05% sodium azide.
Purity/Purification
Ascitic Fluid
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw Storage cycles.
Applications Tested/Suitable for anti-NCOR1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-NCOR1 antibody
IHC-1:100-1:200
Other Notes
Small volumes of anti-NCOR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for NCOR1 purchase
MBS475850 is an antibody targeting NCOR1. Also known as Anti-NCOR1 Mouse mAb. Reactive in Human. Host: Mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for NCOR1. It may not necessarily be applicable to this product.
NCBI Official Full Name
NCOR1, partial
NCBI Official Synonym Full Names
nuclear receptor corepressor 1
NCBI Official Symbol
NCOR1
NCBI Official Synonym Symbols
N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
UniProt Protein Name
Nuclear receptor corepressor 1
Protein Family
Nuclear receptor corepressor
UniProt Gene Name
NCOR1
UniProt Synonym Gene Names
KIAA1047; N-CoR; N-CoR1
NCBI Protein Information
nuclear receptor corepressor 1
NCBI Summary for NCOR1
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Show more UniProt Comments for NCOR1
N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17p12-p11.2
Cellular Component: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; Sin3 complex; spindle microtubule; transcriptional repressor complex
Molecular Function: histone deacetylase binding; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; protein binding; thyroid hormone receptor binding; transcription corepressor activity
Biological Process: cellular lipid metabolic process; circadian rhythm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription from RNA polymerase II promoter
Show more Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17p12-p11.2
Cellular Component: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; Sin3 complex; spindle microtubule; transcriptional repressor complex
Molecular Function: histone deacetylase binding; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; protein binding; thyroid hormone receptor binding; transcription corepressor activity
Biological Process: cellular lipid metabolic process; circadian rhythm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-NCOR1 antibody
| Reference Product | PubMed Publications |
|---|---|
| HDAC3 antibody | >51 publications with NCOR1 and HDAC3 |
| RARA antibody | >12 publications with NCOR1 and RARA |
| THRB antibody | >3 publications with NCOR1 and THRB |
| HDAC9 antibody | >2 publications with NCOR1 and HDAC9 |
| ESR1 antibody | >2 publications with NCOR1 and ESR1 |
| TBL1X antibody | >2 publications with NCOR1 and TBL1X |
| PPARG antibody | >1 publications with NCOR1 and PPARG |
Pathways associated with anti-NCOR1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Activation Of HOX Genes During Differentiation Pathway antibodies | Activation Of HOX Genes During Differentiation Pathway Diagram |
| Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies | Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram |
| Adipogenesis Pathway antibodies | Adipogenesis Pathway Diagram |
| Androgen Receptor Signaling Pathway antibodies | Androgen Receptor Signaling Pathway Diagram |
| BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies | BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram |
| C-MYB Transcription Factor Network Pathway antibodies | C-MYB Transcription Factor Network Pathway Diagram |
| Chromatin Modifying Enzymes Pathway antibodies | Chromatin Modifying Enzymes Pathway Diagram |
| Chromatin Organization Pathway antibodies | Chromatin Organization Pathway Diagram |
| Circadian Clock Pathway antibodies | Circadian Clock Pathway Diagram |
| Circadian Rythm Related Genes Pathway antibodies | Circadian Rythm Related Genes Pathway Diagram |
Diseases associated with anti-NCOR1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Breast Neoplasms Antibodies | >43 publications with NCOR1 and Breast Neoplasms |
| Inflammation Antibodies | >22 publications with NCOR1 and Inflammation |
| Liver Diseases Antibodies | >13 publications with NCOR1 and Liver Diseases |
| Nervous System Diseases Antibodies | >13 publications with NCOR1 and Nervous System Diseases |
| Adenocarcinoma Antibodies | >11 publications with NCOR1 and Adenocarcinoma |
| Fatty Liver Antibodies | >10 publications with NCOR1 and Fatty Liver |
| Disease Models, Animal Antibodies | >9 publications with NCOR1 and Disease Models, Animal |
| Liver Neoplasms Antibodies | >7 publications with NCOR1 and Liver Neoplasms |
| Hyperplasia Antibodies | >6 publications with NCOR1 and Hyperplasia |
| Necrosis Antibodies | >6 publications with NCOR1 and Necrosis |
Organs/Tissues associated with anti-NCOR1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Thyroid Antibodies | >151 publications with NCOR1 and Thyroid |
| Liver Antibodies | >44 publications with NCOR1 and Liver |
| Blood Antibodies | >44 publications with NCOR1 and Blood |
| Brain Antibodies | >39 publications with NCOR1 and Brain |
| Prostate Antibodies | >25 publications with NCOR1 and Prostate |
| Muscle Antibodies | >17 publications with NCOR1 and Muscle |
| Kidney Antibodies | >16 publications with NCOR1 and Kidney |
| Bone Antibodies | >13 publications with NCOR1 and Bone |
| Pituitary Gland Antibodies | >12 publications with NCOR1 and Pituitary Gland |
| Embryonic Tissue Antibodies | >9 publications with NCOR1 and Embryonic Tissue |
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