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> AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

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AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)

(Synonyms: transcription factor AP-2 γ (activating enhancer binding protein 2 γ), transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma), TFAP2G, hAP-2g, ERF1, AP2-γ, AP2-GAMMA, AP2 γ/TFAP2C) Copy Product Info

Synonyms: transcription factor AP-2 γ (activating enhancer binding protein 2 γ), transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma), TFAP2G, hAP-2g, ERF1, AP2-γ, AP2-GAMMA, AP2 γ/TFAP2C

Catalog No. TMPY-02949 Copy Product Info
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).
Species
Human
Expression System
E. coli
TagN-His
Accession NumberQ92754
ConstructionA DNA sequence encoding the mature form of human TFAP2C (Q92754) (Leu128-Val223) was expressed with a polyhistide tag at the N-terminus. Predicted N terminal: His
Protein Purity
> 98 % as determined by SDS-PAGE
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymstranscription factor AP-2 γ (activating enhancer binding protein 2 γ), transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma), TFAP2G, hAP-2g, ERF1, AP2-γ, AP2-GAMMA, AP2 γ/TFAP2C
Research Background
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).
Chemical Properties
Molecular Weight12.3 kDa (predicted); 12-14 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

transcription factor AP-2 gammaERF-1ERF 1activating enhancer binding protein 2 gamma
Related Tags: AP2 Gamma/TFAP2C Protein, Human, Recombinant (His) chemical structure | AP2 Gamma/TFAP2C Protein, Human, Recombinant (His) molecular weight