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Aristolochic acid D [17413-38-6]

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Référence NB-64-61843-1mL

Conditionnement : 1mLx10mM(inDMSO)

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Aristolochic acid D

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Synonyms:

Catalog No. TN1070 Copy Product Info

Purity: 99.96%

Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.

Cas No. 17413-38-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:Orange

Product Introduction

Aristolochic acid D AI Summary

Aristolochic acid D exhibits multiple bioactivities, notably as an inhibitor of CDK2 with an IC50 value of 25000.0 nM. It also demonstrates significant anti-inflammatory properties in human neutrophils by inhibiting superoxide anion generation and elastase release induced by fMLP/CB, with IC50 values of 5.78 µg/mL and 8.49 µg/mL, respectively, after 5 minutes. Additionally, the compound shows efficacy in inhibiting the formation of the Importin beta complex (28183.8 nM) and inducing the dissociation of the RanGTP-induced Rango (6513.1 nM). It acts against Human Flap endonuclease 1 with an IC50 of 56234.1 nM. Specifically, in cancer-related activities, Aristolochic acid D induces DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells, with IC50 values of 1458.1 nM and 103.2 nM respectively. Lastly, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the absence of CPT with an IC50 of 32642.7 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aristolochic Acid D, a derivative of aristolochic acid isolated from the stems of Aristolochia indica, is identified as both a carcinogen and nephrotoxin.

Chemical Properties

Molecular Weight	357.27
Formula	C₁₇H₁₁NO₈
Cas No.	17413-38-6
Smiles	COc1cc(O)cc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O
Relative Density.	1.656 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (15.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7990 mL	13.9950 mL	27.9900 mL	139.9502 mL
5 mM	0.5598 mL	2.7990 mL	5.5980 mL	27.9900 mL
10 mM	0.2799 mL	1.3995 mL	2.7990 mL	13.9950 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

InhibitorinhibitAristolochic acid D

Related Tags: Aristolochic acid D chemical structure | Aristolochic acid D formula | Aristolochic acid D molecular weight