Exhibits antitumor activity. Astin C is a cyclopeptide isolated from the medicinal plant Aster tataricus, inhibits cGAS-STING signaling and the innate inflammatory responses triggered by cytosolic DNAs, inhibits intracellular DNA-induced Ifnb expression with IC50 of 3.42 and 10.83 uM for mouse embryonic fibroblasts (MEFs) and IMR-90 cells; does not affect the expression of IL6 mRNA induced upon treatment with TLR agonists poly(I:C), lipopolysaccharide (LPS), or R837; specifically binds to the C-Terminal Domain of STING (Kd=10 uM, both STING R232 and STING H232); suppresses the recruitment of IRF3 onto the STING signalosome, attenuates host antimicrobial defenses against HSV-1 and listeria monocytogenes, alleviates the autoinflammatory responses in vivo.

Synonyms:
(3R,10R,13R,16S,17R,18S)-17,18-dichloro-3,13-diethyl-10-(hydroxymethyl)-7-phenyl-1,4,8,11,14-pentazabicyclo[14.3.0]nonadecane-2,5,9,12,15-pentone

CAS No:
148057-23-2

Molecular Formula:
C25H33N5O6Cl2

Molecular Weight:
570.47

Purity:
≥95%

Appearance:
Powder

Solubility:
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at 4ºC for 6 months after receipt. Protect from light and air.