Beta-Sitosterol [83-46-5]
Référence T2966-100mg
Conditionnement : 100mg
Marque : TargetMol
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Beta-Sitosterol
(Synonyms: β-Sitosterol, SKF 14463, Cupreol, Beta-Sitosterol, Betaprost, Azuprostat, 22,23-Dihydrostigmasterol) Copy Product Info
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.
Cas No. 83-46-5
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:99.95%
Color:White
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. |
| Targets & IC50 | HCT116 cells:140 μmol/mL, KB cells (48 h):13.82 µM, MCF-7 cells (48 h):36 ± 5.1 µM, KB cells (24 h):32.58 µM, PPL:99.99 ± 1.86 μg/mL, MCF-7 cells (24 h):59 ± 3.2 µM |
| In vitro | Bioactivity-guided isolation from the hexane fraction of E. indica yielded Beta-Sitosterol (β-sitosterol), Stigmasterol, and Lutein. Beta-Sitosterol and Stigmasterol displayed minimal PPL inhibition, with 2.99±0.80% and 2.68±0.38% at 100 μg/mL (242-243 μM) respectively, compared to higher inhibition by Curcumin (IC50=4.92±0.21 μg/mL) and Quercetin (IC50=18.60±0.86 μg/mL). These compounds showed weaker inhibition than literature values (50% PPL inhibition at 100 μg/mL). Beta-Sitosterol, also extracted from Aloe vera, inhibits the growth of L. donovani promastigotes, implicated in visceral leishmaniasis. |
| In vivo | Beta-sitosterol (β-sitosterol) treatment significantly reduced immobility times in mice across all doses tested (10, 20, and 30 mg/kg) in both the Forced Swim Test (FST) and Tail Suspension Test (TST), indicating a notable antidepressant effect. At 30 mg/kg, β-sitosterol's efficacy was comparable to fluoxetine (20 mg/kg) with the most robust effect against the control group (P < 0.001). The percentage decreases in immobility (DID) for FST were 39.27%, 51.23%, and 57.48% for 10, 20, and 30 mg/kg respectively, and for TST were 31.63%, 43.95%, and 53.38% for the same doses, confirming the dose-dependent antidepressant activity of Beta-sitosterol in animal models. |
| Synonyms | β-Sitosterol, SKF 14463, Cupreol, Beta-Sitosterol, Betaprost, Azuprostat, 22,23-Dihydrostigmasterol |
| Molecular Weight | 414.71 |
| Formula | C29H50O |
| Cas No. | 83-46-5 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)10)10)(CC[C@@]2([C@@H](CC[C@H](C(C)C)CC)C)10)10 |
| Relative Density. | 0.9540 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | Ethanol: 3.32 mg/mL (8.01 mM), Sonication is recommended. DMSO: Insoluble | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
Ethanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||