Biotin-Linked Polyclonal Antibody to Apolipoprotein A5 (APOA5)
Référence MBS2061818-1mL
Conditionnement : 1mL
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Apolipoprotein A5 (APOA5) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2061818SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2061818 is an antibody targeting APOA5. Also known as Biotin-Linked Polyclonal Antibody to Apolipoprotein A5 (APOA5). Reactive in Human, Rat, Guinea pig. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Apolipoprotein A5 (APOA5), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Apolipoprotein A5 (APOA5)
Product Gene Name
anti-APOA5 antibody
Product Synonym Names
Apo-A5; APOA-V; APOAV; RAP3; Regeneration-associated protein 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Guinea pig
Form/Format
Liquid
Purity/Purification
Antigen-specific affinity chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against APOA5. It has been selected for its ability to recognize APOA5 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: APOA5 (MBS2002767)
Biotin Conjugated Antibody: APOA5 (MBS2061818)
Biotin Conjugated Antibody: APOA5 (MBS2061818)
Matching Pairs
Biotin Conjugated Antibody: APOA5 (MBS2061818)
Immunogen: APOA5 (MBS2011875)
Immunogen: APOA5 (MBS2011875)
Molecular Weight
41,213 Da
OMIM
AF202889 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Product Categories/Family for anti-APOA5 antibody
Antibody labeling; Cardiovascular biology
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-APOA5 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-APOA5 antibody
Western Blot: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Other Notes
Small volumes of anti-APOA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for APOA5. It may not necessarily be applicable to this product.
NCBI Official Full Name
apolipoprotein A-V
NCBI Official Synonym Full Names
apolipoprotein A5
NCBI Official Symbol
APOA5
NCBI Official Synonym Symbols
RAP3; APOAV
UniProt Protein Name
Apolipoprotein A-V
UniProt Synonym Protein Names
Apolipoprotein A5; Regeneration-associated protein 3
Protein Family
Apolipoprotein
UniProt Gene Name
APOA5
UniProt Synonym Gene Names
RAP3; Apo-AV; ApoA-V
NCBI Protein Information
apolipoprotein A-V
NCBI Summary for APOA5
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]
Show more UniProt Comments for APOA5
APOA5: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family.
Protein type: Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: chylomicron; extracellular region; extracellular space
Molecular Function: cholesterol binding; cholesterol transporter activity; enzyme activator activity; enzyme binding; heparin binding; lipid binding; low-density lipoprotein receptor binding; phosphatidylcholine binding; phospholipid binding
Biological Process: acylglycerol homeostasis; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; lipid transport; lipoprotein metabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; positive regulation of receptor-mediated endocytosis; regulation of cholesterol absorption; reverse cholesterol transport; tissue regeneration; triacylglycerol catabolic process; triacylglycerol metabolic process
Disease: Hyperlipoproteinemia, Type V; Hypertriglyceridemia, Familial
Show more Protein type: Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: chylomicron; extracellular region; extracellular space
Molecular Function: cholesterol binding; cholesterol transporter activity; enzyme activator activity; enzyme binding; heparin binding; lipid binding; low-density lipoprotein receptor binding; phosphatidylcholine binding; phospholipid binding
Biological Process: acylglycerol homeostasis; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; lipid transport; lipoprotein metabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; positive regulation of receptor-mediated endocytosis; regulation of cholesterol absorption; reverse cholesterol transport; tissue regeneration; triacylglycerol catabolic process; triacylglycerol metabolic process
Disease: Hyperlipoproteinemia, Type V; Hypertriglyceridemia, Familial
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-APOA5 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Chylomicron-mediated Lipid Transport Pathway antibodies | Chylomicron-mediated Lipid Transport Pathway Diagram |
| Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies | Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram |
| Lipid Digestion, Mobilization, And Transport Pathway antibodies | Lipid Digestion, Mobilization, And Transport Pathway Diagram |
| Lipoprotein Metabolism Pathway antibodies | Lipoprotein Metabolism Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Lipids And Lipoproteins Pathway antibodies | Metabolism Of Lipids And Lipoproteins Pathway Diagram |
| PPAR Signaling Pathway antibodies | PPAR Signaling Pathway Diagram |
| PPAR Signaling Pathway antibodies | PPAR Signaling Pathway Diagram |
| PPARA Activates Gene Expression Pathway antibodies | PPARA Activates Gene Expression Pathway Diagram |
| Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies | Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram |
Diseases associated with anti-APOA5 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Dyslipidemias Antibodies | >152 publications with APOA5 and Dyslipidemias |
| Hypertriglyceridemia Antibodies | >140 publications with APOA5 and Hypertriglyceridemia |
| Hyperlipidemias Antibodies | >134 publications with APOA5 and Hyperlipidemias |
| Cardiovascular Diseases Antibodies | >121 publications with APOA5 and Cardiovascular Diseases |
| Heart Diseases Antibodies | >71 publications with APOA5 and Heart Diseases |
| Atherosclerosis Antibodies | >70 publications with APOA5 and Atherosclerosis |
| Arteriosclerosis Antibodies | >48 publications with APOA5 and Arteriosclerosis |
| Insulin Resistance Antibodies | >41 publications with APOA5 and Insulin Resistance |
| Diabetes Mellitus, Type 2 Antibodies | >27 publications with APOA5 and Diabetes Mellitus, Type 2 |
| Liver Diseases Antibodies | >15 publications with APOA5 and Liver Diseases |
Organs/Tissues associated with anti-APOA5 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >43 publications with APOA5 and Liver |
| Lung Antibodies | >1 publications with APOA5 and Lung |