Caspase-3 Antibody
Référence OAED00052
Conditionnement : 50ug
Marque : Aviva Systems Biology
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Caspase-3 Antibody (OAED00052)
| Datasheets/Manuals | Printable datasheet for Caspase-3 Antibody (OAED00052) (OAED00052) |
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| Predicted Species Reactivity | Bovine|Chicken|Dog|Guinea Pig|Hamster|Human|Monkey|Mouse|Porcine|Rabbit|Rat|Sheep|Xenopus |
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| Product Format | Liquid. Antiserum. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | Western blot |
| Reconstitution and Storage | Long term storage at -20°C. Avoid freeze/thaw cycles. |
| Immunogen | Synthetic peptide corresponding to a portion of human caspase-3 . The sequence differs from rat caspase-3 by 1 aa and from mouse by 2 aa. |
| Intended Use | For research use only. |
| Application Info | WB: 1:5000 |
| Reference | Rapid cold-hardening protects Drosophila melanogaster from cold-induced apoptosis: R.E. Lee, et al. ; Apoptosis 12, 1183 (2007), Application(s): WB using drosophila cell lysates, Abstract; |
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| Gene Symbol | CASP3 |
| Gene Full Name | caspase 3 |
| Alias Symbols | apopain;CASP-3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CPP32;CPP-32;CPP32B;cysteine protease CPP32;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1. |
| NCBI Gene Id | 836 |
| Protein Name | Caspase-3 |
| Description of Target | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
| Uniprot ID | P42574 |
| Molecular Weight | ~36 kDa |
