caspase-9 p10 Polyclonal Antibody, PE-Cy7 Conjugated
Référence bs-8502R-PE-Cy7
Conditionnement : 100uL
Marque : Bioss
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Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-8502R-PE-Cy7 |
| Product Name | caspase-9 p10 Polyclonal Antibody, PE-Cy7 Conjugated |
| Applications | WB, FCM |
| Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Dog, Cow, Pig, Horse, Chicken, Rabbit |
| Specifications | |
| Conjugation | PE-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human caspase-9 subunit p10 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 842 |
| Swiss Prot | P55211 |
| Subcellular location | Secreted |
| Synonyms | MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9 |
| Background | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |