CD161 Monoclonal Antibody
Référence MBS668177-0,025mg
Conditionnement : 0.025mg
Marque : MyBiosource
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Expression analysis of CD161. Anti-CD161 antibody (Clone: ABM2D74) was tested at 2 ug/ml on Jurkat lysate.
Immunohistochemical analysis of CD161 in small cell carcinoma of esophagus using CD161 antibody (Clone: ABM2D74) at 5 ug/ml.
Immunohistochemical analysis of CD161 in Transitional cell carcinoma of urinary bladder using CD161 antibody (Clone: ABM2D74) at 5 ug/ml.
Cell Surface flow analysis of hCD161 in PBMC (Lymphocytes) using 0.2ug/10^6 cells of CD161 clone (ABM2D74). Green represents isotype control; red represents anti-hCD161 antibody. Goat anti-mouse PE conjugated secondary antibody was used.
CD161 Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS668177CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin super family. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially… More details
Product Overview
Online Datasheet in PDFProduct Name
CD161, Monoclonal Antibody
Full Product Name
CD161 Monoclonal Antibody
Product Gene Name
anti-CD161 antibody
Clonality
Monoclonal
Isotype
Mouse IgG1, Kappa
Clone Number
ABM2D74
Host
Mouse
Species Reactivity
Human
Form/Format
Purified (Liquid)
Purity/Purification
Protein G chromatography
Preparation and Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C.
Avoid repeated freeze thaw cycles.
Avoid repeated freeze thaw cycles.
OMIM
602890
Immunogen
A full length of human CD161 protein were used as the immunogen for this antibody.
Content
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% and 0.05% sodium azide. Sodium azide is highly toxic.
Product Categories/Family for anti-CD161 antibody
Immunology
Applications Tested/Suitable for anti-CD161 antibody
Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC)
Application Notes for anti-CD161 antibody
WB: 2-4 ug/ml
IHC: 5 ug/ml
FC: 0.2-0.5 ug/106 cells
IHC: 5 ug/ml
FC: 0.2-0.5 ug/106 cells
Other Notes
Small volumes of anti-CD161 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CD161 purchase
MBS668177 is an antibody targeting CD161. Also known as CD161 Monoclonal Antibody. Reactive in Human. Host: Mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for CD161. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
killer cell lectin-like receptor subfamily B member 1
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily B, member 1
NCBI Official Symbol
KLRB1
NCBI Official Synonym Symbols
NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A
UniProt Protein Name
Killer cell lectin-like receptor subfamily B member 1
UniProt Synonym Protein Names
C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD_antigen: CD161
Protein Family
Killer cell lectin-like receptor subfamily
UniProt Gene Name
KLRB1
UniProt Synonym Gene Names
CLEC5B; NKRP1A; NKR-P1A
UniProt Entry Name
KLRB1_HUMAN
NCBI Protein Information
killer cell lectin-like receptor subfamily B member 1
NCBI Summary for CD161
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for CD161
KLRB1: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: plasma membrane; integral to membrane
Molecular Function: transmembrane receptor activity; carbohydrate binding
Biological Process: cell surface receptor linked signal transduction
Show more Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: plasma membrane; integral to membrane
Molecular Function: transmembrane receptor activity; carbohydrate binding
Biological Process: cell surface receptor linked signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD161 antibody
| Reference Product | PubMed Publications |
|---|---|
| CD1D antibody | >19 publications with CD161 and CD1D |
| NCAM1 antibody | >17 publications with CD161 and NCAM1 |
| CLEC2D antibody | >12 publications with CD161 and CLEC2D |
| RORC antibody | >8 publications with CD161 and RORC |
| SRC antibody | >3 publications with CD161 and SRC |
| LCK antibody | >3 publications with CD161 and LCK |
| NCR2 antibody | >2 publications with CD161 and NCR2 |
| SMPD1 antibody | >1 publications with CD161 and SMPD1 |
| CLEC2A antibody | >1 publications with CD161 and CLEC2A |
Pathways associated with anti-CD161 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Malaria Pathway antibodies | Malaria Pathway Diagram |
| Malaria Pathway antibodies | Malaria Pathway Diagram |
Diseases associated with anti-CD161 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >18 publications with CD161 and Inflammation |
| Nervous System Diseases Antibodies | >16 publications with CD161 and Nervous System Diseases |
| Necrosis Antibodies | >14 publications with CD161 and Necrosis |
| Lung Diseases Antibodies | >10 publications with CD161 and Lung Diseases |
| Melanoma Antibodies | >10 publications with CD161 and Melanoma |
| Demyelinating Diseases Antibodies | >9 publications with CD161 and Demyelinating Diseases |
| Cardiovascular Diseases Antibodies | >5 publications with CD161 and Cardiovascular Diseases |
| Drug-Induced Liver Injury Antibodies | >3 publications with CD161 and Drug-Induced Liver Injury |
| Ovarian Neoplasms Antibodies | >2 publications with CD161 and Ovarian Neoplasms |
| Memory Disorders Antibodies | >2 publications with CD161 and Memory Disorders |
Organs/Tissues associated with anti-CD161 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >203 publications with CD161 and Blood |
| Intestine Antibodies | >15 publications with CD161 and Intestine |
| Spleen Antibodies | >14 publications with CD161 and Spleen |
| Lung Antibodies | >11 publications with CD161 and Lung |
| Vascular Antibodies | >8 publications with CD161 and Vascular |
| Heart Antibodies | >4 publications with CD161 and Heart |
| Kidney Antibodies | >3 publications with CD161 and Kidney |
| Pharynx Antibodies | >1 publications with CD161 and Pharynx |
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