CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP)
Référence MBS6122153-5x0,1mL
Conditionnement : 5x0.1mL
Marque : MyBiosource
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CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP)
Formalin-fixed, paraffin-embedded human tonsil stained with CD35 Ab. Note cell membrane staining.
CD35 Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6122153MBS6122153 is an antibody targeting CD35. Also known as CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP).… More details
Product Overview
Online Datasheet in PDFProduct Name
CD35, Monoclonal Antibody
Full Product Name
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP)
Product Gene Name
anti-CD35 antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
E11
Host
Mouse
Species Reactivity
Human, Monkey
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes human CD35. Species Crossreactivity: baboon, cynomolgus monkey, rhesus monkey. No cross-reaction with CR2.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing alkaline phosphatase conjugates will result in a substantial loss of activity.
Applications Tested/Suitable for anti-CD35 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CD35 antibody
IP: 1-2ug/500ug protein lysate
IF: 1-2ug/ml
WB: 0.5-1ug/ml
Applications are based on unconjugated antibody.
IF: 1-2ug/ml
WB: 0.5-1ug/ml
Applications are based on unconjugated antibody.
Product References and Citations for anti-CD35 antibody
1. Hogg N, et. al. European Journal of Immunology, 1984, 14:236-43.
Other Notes
Small volumes of anti-CD35 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CD35. It may not necessarily be applicable to this product.
NCBI Official Full Name
complement receptor type 1 isoform S
NCBI Official Synonym Full Names
complement component (3b/4b) receptor 1 (Knops blood group)
NCBI Official Symbol
CR1
NCBI Official Synonym Symbols
KN; C3BR; C4BR; CD35
UniProt Protein Name
Complement receptor type 1
UniProt Synonym Protein Names
C3b/C4b receptor
Protein Family
Complement receptor
UniProt Gene Name
CR1
UniProt Synonym Gene Names
C3BR
UniProt Entry Name
CR1_HUMAN
NCBI Protein Information
complement receptor type 1; C3-binding protein; C3b/C4b receptor; CD35 antigen; Knops blood group antigen
NCBI Summary for CD35
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for CD35
CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding
Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway
Disease: Knops Blood Group System; Malaria, Susceptibility To
Show more Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding
Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway
Disease: Knops Blood Group System; Malaria, Susceptibility To
Research Articles on CD35
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD35 antibody
| Reference Product | PubMed Publications |
|---|---|
| CR2 antibody | >550 publications with CD35 and CR2 |
| CD46 antibody | >71 publications with CD35 and CD46 |
| PTGS2 antibody | >5 publications with CD35 and PTGS2 |
| IL8 antibody | >4 publications with CD35 and IL8 |
| CFI antibody | >2 publications with CD35 and CFI |
| PTPN13 antibody | >1 publications with CD35 and PTPN13 |
| C5AR1 antibody | >1 publications with CD35 and C5AR1 |
Pathways associated with anti-CD35 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement Cascade Pathway antibodies | Complement Cascade Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Immune System Pathway antibodies | Immune System Pathway Diagram |
| Innate Immune System Pathway antibodies | Innate Immune System Pathway Diagram |
| Legionellosis Pathway antibodies | Legionellosis Pathway Diagram |
| Legionellosis Pathway antibodies | Legionellosis Pathway Diagram |
Diseases associated with anti-CD35 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Immune System Diseases Antibodies | >603 publications with CD35 and Immune System Diseases |
| Inflammation Antibodies | >171 publications with CD35 and Inflammation |
| Nervous System Diseases Antibodies | >140 publications with CD35 and Nervous System Diseases |
| Alzheimer Disease Antibodies | >88 publications with CD35 and Alzheimer Disease |
| Kidney Diseases Antibodies | >81 publications with CD35 and Kidney Diseases |
| Necrosis Antibodies | >70 publications with CD35 and Necrosis |
| Respiratory Tract Diseases Antibodies | >69 publications with CD35 and Respiratory Tract Diseases |
| Malaria Antibodies | >62 publications with CD35 and Malaria |
| Malaria, Falciparum Antibodies | >53 publications with CD35 and Malaria, Falciparum |
| Liver Diseases Antibodies | >47 publications with CD35 and Liver Diseases |
Organs/Tissues associated with anti-CD35 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >1487 publications with CD35 and Blood |
| Vascular Antibodies | >86 publications with CD35 and Vascular |
| Lymph Node Antibodies | >58 publications with CD35 and Lymph Node |
| Lymph Antibodies | >41 publications with CD35 and Lymph |
| Intestine Antibodies | >27 publications with CD35 and Intestine |
| Nerve Antibodies | >26 publications with CD35 and Nerve |
| Connective Tissue Antibodies | >15 publications with CD35 and Connective Tissue |
| Uterus Antibodies | >8 publications with CD35 and Uterus |
| Mouth Antibodies | >4 publications with CD35 and Mouth |
| Placenta Antibodies | >3 publications with CD35 and Placenta |