CD8a

Référence 397030-100ug

Conditionnement : 100ug

Marque : US Biological

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397030CD8a

Specifications
Clone TypeMonoclonal
Hostmouse
Sourcebovine
Swiss ProtP31783
IsotypeIgG2a
GradeSupernatant
ApplicationsFC
CrossreactivityBo Gt Sh
Shipping TempBlue Ice
Storage Temp-20°C

It is involved in the activation of the cytotoxic T-cell response and the clearance of virally infected cells. CD8 is predominantly present either as homodimer or a multimer of the alpha chain or as heterodimer of the alpha and beta chains. Bovine CD8 differs from the CD8 molecules of other animal species and shares 57.85% identity with porcine, 37.70% with mouse, 27.50 % with chicken, and 20.69% identity with carp. CD8a recognizes bovine CD8 lymphocytes and gamma delta CD8+ lymphocytes. In addition it reacts with the CD8 lymphocytes of water buffalo.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilution:
Flow Cytometry: Neat 1:10
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG2a|Clone No: 7C2B|Host: mouse|Source: bovine|Concentration: Not determined|Form: Supplied as a liquid in 0.09% sodium azide.|Purity: Supernatant|Specificity: Recognizes bovine CD8a. Species Crossreactivity: goat, sheep, bison and water buffalo.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a liquid in 0.09% sodium azide.
Purity
Supernatant
Specificity
Recognizes bovine CD8a. Species Crossreactivity: goat, sheep, bison and water buffalo.
References
1. Koo H.C. et al. (2004) Analysis of the immune response to Mycobacterium avium subsp. paratuberculosis in experimentally infected calves. Infect Immun. 72 (12): 6870-83.|2. Allen A.J. et al. (2009) Development of a bovine ileal cannulation model to study the immune response and mechanisms of pathogenesis of paratuberculosis. Clin Vaccine Immunol. 16 (4): 453-63.