Specifications

Product Data
Applications	IHC, WB
Recommended Dilution	WB: 500-2000 WB positive control: Jurkat cell lysate IHC: 100-200 Positive control: Human tonsil Predicted cell location: Cytoplasm
Reactivities	Human, Mouse
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 13-300 amino acids of human Cyclin-dependent kinase 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	37 kDa
Gene Name	cyclin-dependent kinase 6
Database Link	NP_001138778 Entrez Gene 12571 MouseEntrez Gene 1021 Human UniProt ID Q00534
Background	The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28; and Schizosaccharomyces pombe cdc2; and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase; which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase; as well as CDK4; has been shown to phosphorylate; and thus regulate the activity of; tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants; encoding the same protein; have been identified.
Synonyms	MCPH12; PLSTIRE
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer