Cefotaxime [63527-52-6]
Référence NB-64-42372-500mg
Conditionnement : 500mg
Marque : Neo Biotech
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Cefotaxime
Catalog No. T7733 Copy Product Info
Purity: 99.77%
Cefotaxime is an inhibitor of penicillin binding protein.
Cefotaxime
Copy Product InfoCefotaxime is an inhibitor of penicillin binding protein.
Cas No. 63527-52-6
Product Introduction
Cefotaxime AI Summary
Cefotaxime exhibits broad-spectrum antibacterial activity against a variety of bacterial pathogens, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus pyogenes, with notable low minimum inhibitory concentrations (MIC) indicative of its potent antibacterial efficacy. Specific MIC values include 0.06 ug/mL against Klebsiella pneumoniae and 0.03 ug/mL against Escherichia coli strains, highlighting its broad applicability. Additionally, the compound shows inhibitory effects on penicillin-binding proteins (PBPs) and various beta-lactamases, enhancing its effectiveness against resistant bacterial strains. In vivo murine models evidenced its therapeutic potential at effective doses (ED50) for infectious treatments. While demonstrating strong in vitro and in vivo results, Cefotaxime exhibits differential activity with reduced effectiveness against multi-resistant strains such as certain Pseudomonas aeruginosa and Staphylococcus aureus strains. Documented pharmacokinetic properties indicate a short half-life and high clearance rate, necessitating considerations in dosing regimens for clinical applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cefotaxime is an inhibitor of penicillin binding protein. |
| Molecular Weight | 455.47 |
| Formula | C16H17N5O7S2 |
| Cas No. | 63527-52-6 |
| Smiles | C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1COC(C)=O)16 |
| Relative Density. | 1.8 g/cm3 |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 255 mg/mL (559.86 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.25 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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