Conditionnement : 50mg
Téléphone : +1 850 650 7790
Synonyms:
| Description | CKS-17, a synthetic retroviral envelope peptide, embodies conserved amino acid sequences found in the transmembrane envelope proteins of various animal and human retroviruses. This immunomodulatory epitope exerts suppressive effects on a range of immune functions [1] [2] [3]. |
| In vitro | CKS-17 stimulates elevated intracellular cAMP levels in THP-1 cells by activating adenylate cyclase [1]. |
| In vivo | CKS-17, at a concentration of 10 μM and administered intradermally, suppresses delayed-type hypersensitivity responses to sheep erythrocytes in the hind paws of B6AF1 and C57BL/6J mice [2]. |
| Molecular Weight | 1942.27 |
| Formula | C87H148N26O24 |
| Cas No. | 99273-04-8 |
| Smiles | [C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)CCC(N)=O)=O)CC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CC(C)C)=O)CC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)CCC(O)=O)=O)CCCCN)=O)CC(C)C)=O |
| Sequence | Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu |
| Sequence Short | LQNRRGLDLLFLKEGGL |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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