Biovalley > Csf1r Antibody - FITC Conjugated
Csf1r Antibody - FITC Conjugated
Référence OACA01489
Conditionnement : 100ug
Marque : Aviva Systems Biology
SKU
OACA01489
Availability: Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks
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Csf1r Antibody - FITC Conjugated (OACA01489)
| Datasheets/Manuals | Printable datasheet for Csf1r Antibody - FITC Conjugated (OACA01489) (OACA01489) |
|---|
| Predicted Species Reactivity | Mouse |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | FITC |
| Application | WB |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Mouse Macrophage colony-stimulating factor 1 protein (33-262AA) |
| Purification | Protein G Purified |
| Purity | Caprylic Acid Ammonium Sulfate Precipitation purified |
| Storage Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Reference | [1] Murine c-fms cDNA: cloning, sequence analysis and retroviral expression.'Rothwell V.M., Rohrschneider L.R.Oncogene Res. 1:311-324(1987) [2] The transcriptional landscape of the mammalian genome.'Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.Science 309:1559-1563(2005) [3] Reassessment of the murine c-fms proto-oncogene sequence.'de Parseval N., Bordereaux D., Gisselbrecht S., Sola B.Nucleic Acids Res. 21:750-750(1993) |
|---|---|
| Gene Symbol | Csf1 |
| Gene Full Name | colony stimulating factor 1 (macrophage) |
| Alias Symbols | C87615;Csf;CSF-;Csfm;macrophage colony-stimulating factor 1;M-CS;MCSF;op;osteopetrosis. |
| NCBI Gene Id | 12977 |
| Protein Name | Macrophage colony-stimulating factor 1 |
| Description of Target | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Uniprot ID | P07141 |
Protein interactions
| Name | # of Products |
|---|---|
| Cbl | 471 |
| Cltc | 96 |
| Csf1r | 51 |
| Grb2 | 1020 |
| Hspa8 | 331 |
| Inpp5d | 106 |
| Nono | 82 |
| Nr0b2 | 121 |
| Pik3r1 | 517 |
| Ptpn11 | 309 |
| Sfpi1 | 13 |
| Sfpq | 109 |
| Sos1 | 185 |
| Ubc | 7030 |
Biological pathways
| Name | # of Products |
|---|---|
| Cellular response to macrophage colony-stimulating factor stimulus | 12 |
| Osteoclast differentiation | 53 |
| Peptidyl-tyrosine phosphorylation | 165 |
| Phosphatidylinositol metabolic process | 21 |
| Phosphatidylinositol-mediated signaling | 285 |
| Positive regulation of cell migration | 287 |
| Positive regulation of cell proliferation | 582 |
| Positive regulation of ERK1 and ERK2 cascade | 194 |
| Positive regulation of protein serine/threonine kinase activity | 20 |
| Positive regulation of tyrosine phosphorylation of Stat3 protein | 101 |
| Protein autophosphorylation | 356 |
| Regulation of actin cytoskeleton reorganization | 36 |
| Regulation of bone resorption | 52 |
| Regulation of cell shape | 126 |
| Ruffle organization | 27 |
| Transmembrane receptor protein tyrosine kinase signaling pathway | 153 |
Biological process
| Name | # of Products |
|---|---|
| Cell proliferation | 293 |
| Cell-cell junction maintenance | 5 |
| Cellular response to cytokine stimulus | 17 |
| Cellular response to macrophage colony-stimulating factor stimulus | 6 |
| Cytokine-mediated signaling pathway | 229 |
| Hemopoiesis | 78 |
| Inflammatory response | 339 |
| Innate immune response | 300 |
| Osteoclast differentiation | 29 |
| Peptidyl-tyrosine phosphorylation | 72 |
| Phosphatidylinositol metabolic process | 15 |
| Phosphatidylinositol-mediated signaling | 74 |
| Phosphorylation | 101 |
| Positive regulation of cell migration | 150 |
| Positive regulation of cell motility | 15 |
| Positive regulation of cell proliferation | 483 |
| Positive regulation of chemokine secretion | 10 |
| Positive regulation of ERK1 and ERK2 cascade | 103 |
| Positive regulation of osteoclast differentiation | 39 |
| Positive regulation of protein phosphorylation | 125 |
| Positive regulation of protein serine/threonine kinase activity | 16 |
| Positive regulation of protein tyrosine kinase activity | 17 |
| Positive regulation of tyrosine phosphorylation of Stat3 protein | 43 |
| Protein autophosphorylation | 150 |
| Protein phosphorylation | 451 |
| Regulation of actin cytoskeleton reorganization | 10 |
| Regulation of bone resorption | 8 |
| Regulation of cell shape | 99 |
| Ruffle organization | 14 |
| Signal transduction | 1058 |
| Transmembrane receptor protein tyrosine kinase signaling pathway | 67 |
Cellular components
| Name | # of Products |
|---|---|
| Cell surface | 369 |
| Integral to membrane | 2793 |
| Intracellular | 1678 |
| Membrane | 2769 |
| Plasma membrane | 2678 |
| Receptor complex | 21 |
Protein function
| Name | # of Products |
|---|---|
| ATP binding | 2814 |
| Cytokine binding | 74 |
| Kinase activity | 353 |
| Macrophage colony-stimulating factor receptor activity | 12 |
| Nucleotide binding | 3928 |
| Protein binding | 12191 |
| Protein homodimerization activity | 1852 |
| Protein kinase activity | 636 |
| Protein tyrosine kinase activity | 369 |
| Receptor activity | 3624 |
| Transferase activity | 1042 |
| Transferase activity, transferring phosphorus-containing groups | 127 |
| Transmembrane receptor protein tyrosine kinase activity | 157 |
Diseases
| Name | # of Products |
|---|---|
| Proto-oncogene | 793 |
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Phospho-CSFR (Tyr723) Colorimetric Cell-Based ELISA Kit (OKAG01687)Catalog #: OKAG01687Application: ELISAKit Range: At least 5000 cells/wellFormat: 2 x 96-Well Microplates -
Phospho-CSFR (Tyr561) Colorimetric Cell-Based ELISA Kit (OKAG01770)Catalog #: OKAG01770Application: ELISAKit Range: At least 5000 cells/wellFormat: 2 x 96-Well Microplates -
CSF1R Antibody (OAAB18690)Catalog #: OAAB18690Clone: 1486CT328.53.37Application: FC,IHC-P,WBFormat: Liquid. PBS with 0.09% (W/V) sodium azide. -
CSF1R/M-CSFR ELISA Kit (Mouse) (OKBB00441)Catalog #: OKBB00441Application: ELISAKit Range: 62.5 pg/ml - 4,000 pg/mlSensitivity: <10 pg/ml


