| Size | |
|---|---|
| 100µg | Inquiry |
Dispatch Time: About 3 working days
- Product Name
- CTNNB1 antibody
- Catalogue No.
- FNab09871
- Size
- 100μg
- Form
- liquid
- Purification
- protein A+G purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 5D7
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- catenin(cadherin-associated protein), beta 1, 88kDa
- Alternative Names
- Catenin beta-1|Beta-catenin|CTNNB1|CTNNB antibody
- UniProt ID
- P35222
- Observed MW
- 90 kDa
Application
- Tested Applications
- ELISA, IF, WB, IHC, IP
- Recommended dilution
- WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab09781(B-catenin antibody) at dilution of 1:5000 
IP Result of anti-beta-Catenin (IP:FNab09871, 4ug; Detection:FNab09871 1:500) with mouse liver tissue lysate 6400ug. 
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09781(B-catenin Antibody) at dilution of 1:200 - Background
- The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.