DAB1 Antibody
Référence MBS8583786-0,1mL-FITC
Conditionnement : 0.1mL(FITC)
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
DAB1 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8583786MBS8583786 is an antibody targeting DAB1. Also known as DAB1 Antibody. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to DAB1 More details
Product Overview
Online Datasheet in PDFProduct Name
DAB1, Polyclonal Antibody
Full Product Name
DAB1 Antibody
Product Gene Name
anti-DAB1 antibody
Product Synonym Names
Disabled homolog 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of DAB1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
63,775 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (57463579..58716211, complement). Location: 1p32-p31
OMIM
603448
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DAB1. The exact sequence is proprietary.
Product Categories/Family for anti-DAB1 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DAB1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-DAB1 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-DAB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for DAB1. It may not necessarily be applicable to this product.
NCBI Official Full Name
disabled homolog 1
NCBI Official Synonym Full Names
Dab, reelin signal transducer, homolog 1 (Drosophila)
NCBI Official Symbol
DAB1
UniProt Protein Name
Disabled homolog 1
Protein Family
Disabled
UniProt Gene Name
DAB1
UniProt Entry Name
DAB1_HUMAN
NCBI Protein Information
disabled homolog 1
NCBI Summary for DAB1
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for DAB1
DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: neuron projection; cell soma; membrane; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; cytosol; brush border
Molecular Function: phosphoinositide 3-kinase binding
Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; response to drug; Golgi localization; cerebellum structural organization; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; positive regulation of protein kinase activity; negative regulation of astrocyte differentiation; dendrite development; midgut development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
Show more Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: neuron projection; cell soma; membrane; apical part of cell; perinuclear region of cytoplasm; postsynaptic density; cytosol; brush border
Molecular Function: phosphoinositide 3-kinase binding
Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; response to drug; Golgi localization; cerebellum structural organization; ventral spinal cord development; negative regulation of cell adhesion; adult walking behavior; small GTPase mediated signal transduction; radial glia guided migration of Purkinje cell; positive regulation of protein kinase activity; negative regulation of astrocyte differentiation; dendrite development; midgut development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-DAB1 antibody
| Reference Product | PubMed Publications |
|---|---|
| VLDLR antibody | >62 publications with DAB1 and VLDLR |
| SRC antibody | >48 publications with DAB1 and SRC |
| RELN antibody | >28 publications with DAB1 and RELN |
| APP antibody | >20 publications with DAB1 and APP |
| CDK5 antibody | >15 publications with DAB1 and CDK5 |
| CRKL antibody | >13 publications with DAB1 and CRKL |
| CRK antibody | >12 publications with DAB1 and CRK |
| LRP8 antibody | >7 publications with DAB1 and LRP8 |
| PAFAH1B1 antibody | >5 publications with DAB1 and PAFAH1B1 |
| APLP1 antibody | >4 publications with DAB1 and APLP1 |
Pathways associated with anti-DAB1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies | Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram |
| Reelin Signaling Pathway antibodies | Reelin Signaling Pathway Diagram |
Diseases associated with anti-DAB1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Movement Disorders Antibodies | >9 publications with DAB1 and Movement Disorders |
| Disease Models, Animal Antibodies | >4 publications with DAB1 and Disease Models, Animal |
| Pain Antibodies | >3 publications with DAB1 and Pain |
| Neoplasms, Experimental Antibodies | >3 publications with DAB1 and Neoplasms, Experimental |
| Inflammation Antibodies | >2 publications with DAB1 and Inflammation |
| Mood Disorders Antibodies | >2 publications with DAB1 and Mood Disorders |
| Abnormalities, Drug-Induced Antibodies | >1 publications with DAB1 and Abnormalities, Drug-Induced |
| Microcephaly Antibodies | >1 publications with DAB1 and Microcephaly |
| Neurobehavioral Manifestations Antibodies | >1 publications with DAB1 and Neurobehavioral Manifestations |
| Breast Neoplasms Antibodies | >1 publications with DAB1 and Breast Neoplasms |
Organs/Tissues associated with anti-DAB1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >229 publications with DAB1 and Brain |
| Embryonic Tissue Antibodies | >72 publications with DAB1 and Embryonic Tissue |
| Eye Antibodies | >14 publications with DAB1 and Eye |
| Liver Antibodies | >7 publications with DAB1 and Liver |
| Kidney Antibodies | >5 publications with DAB1 and Kidney |
| Lung Antibodies | >2 publications with DAB1 and Lung |
| Testis Antibodies | >1 publications with DAB1 and Testis |