Dcr-1 Antibody - middle region
Référence OAAB15146
Conditionnement : 400ul
Marque : Aviva Systems Biology
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Dcr-1 Antibody - middle region (OAAB15146)
| Datasheets/Manuals | Printable datasheet for Dcr-1 Antibody - middle region (OAAB15146) |
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| Predicted Species Reactivity | Caenorhabditis elegans |
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| Product Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | WB |
| Additional Information | Precautions: Dcr-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| :: | Function: Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids from the Central region of human Dcr-1. |
| Predicted Homology Based on Immunogen Sequence | C.Elegans |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Application Info | WB: 1:1000 |
| Gene Symbol | dcr-1 |
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| Alias Symbols | CELE_K12H4.8, Death-promoting deoxyribonuclease. |
| NCBI Gene Id | 176138 |
| Protein Name | Death-promoting deoxyribonuclease [Caenorhabditis elegans]|Endoribonuclease dcr-1 |
| Description of Target | Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272). |
| Uniprot ID | P34529 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_498761.2 |
| Molecular Weight | 218423 |