Biovalley > Digitoxose [527-52-6]
Digitoxose [527-52-6]
Référence MD00961-2mg
Conditionnement : 2mg
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Marque : Biosynth
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
CAS No
[527-52-6]
Synonyms
2,6-Dideoxy-D-ribohexose
Product Code
MD00961
MDL No
MFCD28988641
MOL file
Chemical Formula
C6H12O4
Molecular Weight
148.16 g/mol
Smiles
C[C@H]1OC(O)C[C@H](O)[C@@H]1O
Long Term Storage
store at 2°C - 8°C, close container well
Storage
store at 2°C - 8°C, close container well
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29329900 - USA: 2932999090 - Slovakia: 2932990090 - UK: 2932990000 - China: 2932999099
Digitoxose is a deoxy sugar, which is an integral component of certain cardiac glycosides. These glycosides, such as digitoxin, are predominantly sourced from the leaves of the digitalis species, particularly Digitalis purpurea or Digitalis lanata. The sugar moiety, digitoxose, is critical for the glycoside's ability to exert its pharmacological effects through interactions with cellular components.
The mode of action of digitoxose, once it is part of the glycoside, involves inhibiting the sodium-potassium ATPase pump in cardiac cells. This inhibition results in increased intracellular sodium, which subsequently leads to increased intracellular calcium via the sodium-calcium exchanger. Elevated calcium levels enhance cardiac contractility, making digitoxose-containing glycosides invaluable in the treatment of certain heart conditions.
Digitoxose and its glycosides are primarily applied in the management of heart failure and arrhythmias, where they work to increase the force of heart contractions and maintain an appropriate rhythm. Their usage, however, requires careful dosing and monitoring due to the narrow therapeutic window and potential for toxicity.
The mode of action of digitoxose, once it is part of the glycoside, involves inhibiting the sodium-potassium ATPase pump in cardiac cells. This inhibition results in increased intracellular sodium, which subsequently leads to increased intracellular calcium via the sodium-calcium exchanger. Elevated calcium levels enhance cardiac contractility, making digitoxose-containing glycosides invaluable in the treatment of certain heart conditions.
Digitoxose and its glycosides are primarily applied in the management of heart failure and arrhythmias, where they work to increase the force of heart contractions and maintain an appropriate rhythm. Their usage, however, requires careful dosing and monitoring due to the narrow therapeutic window and potential for toxicity.