DOK5 Recombinant Protein
Référence OPCA01569-1MG
Conditionnement : 1mg
Marque : Aviva Systems Biology
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DOK5 Recombinant Protein (Human) (OPCA01569)
| Datasheets/Manuals | Printable datasheet for DOK5 Recombinant Protein (Human) (OPCA01569) |
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| Predicted Species Reactivity | Homo sapiens|Human |
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| Product Format | Liquid or Lyophilized powder |
| Host | Human |
| Additional Information | Relevance: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assbly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Reconstitution and Storage | -20°C or -80°C |
| Formulation | 20 mM Tris-HCl based buffer, pH 8.0 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Peptide Sequence | MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH |
| Protein Sequence | MECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH |
| Storage Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Source | E.coli |
| Protein Range | 1-198 aa |
| Tag | N-terminal 6xHis-SUMO-tagged |
| Reference | The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) |
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| Gene Symbol | DOK5 |
| Gene Full Name | docking protein 5 |
| Alias Symbols | C20orf180, docking protein 5, downstream of tyrosine kinase 5, insulin receptor substrate 6, IRS-6, IRS6. |
| NCBI Gene Id | 55816 |
| Protein Name | Docking protein 5 |
| Description of Target | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| Uniprot ID | Q9P104 |
| Protein Accession # | NP_060901.2 |
| Nucleotide Accession # | NM_018431.4 |
| Protein Size (# AA) | Partial of Isoform 2 |
| Molecular Weight | 38.8 kDa |
