DTT [3483-12-3]
Référence T5370-500mg
Conditionnement : 500mg
Marque : TargetMol
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
DTT
(Synonyms: DL-Dithiothreitol) Copy Product Info
DTT (DL-Dithiothreitol) is a strong reducing agent. DTT has anti-disulfide ptosis activity and, upon oxidation, forms a stable six-membered ring with internal disulfide bonds.
Cas No. 3483-12-3
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:99.91%
Color:White
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DTT (DL-Dithiothreitol) is a strong reducing agent. DTT has anti-disulfide ptosis activity and, upon oxidation, forms a stable six-membered ring with internal disulfide bonds. |
| Targets & IC50 | NMN:250 μM/mg, 5-LOX:0.42 µM ± 0.11 log units |
| In vitro | METHODS: DLD-1 and HCT116 cells under glucose starvation were treated with DTT (0.5 mM) for 12 hours, and PI-positive dead cells were analyzed by flow cytometry. RESULTS: DTT can prevent disulfide stress in DLD-1 and HCT116 cells under glucose starvation and inhibit disulfide death of the cells. [1] |
| Synonyms | DL-Dithiothreitol |
| Molecular Weight | 154.25 |
| Formula | C4H10O2S2 |
| Cas No. | 3483-12-3 |
| Smiles | [C@H]([C@@H](CS)O)(CS)O |
| Relative Density. | 1.302g/cm3 |
| Storage | Store under nitrogen,Keep away from direct sunlight,Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 200 mg/mL (1296.6 mM), Sonication is recommended. DMSO: 242 mg/mL (1568.88 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (32.41 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||