DYNLL1, aa1-89, Recombinant, Human (Dynein Light Chain 1, Cytoplasmic, 8kD Dynein Light Chain, DLC8, Dynein Light Chain LC8-type 1, Protein Inhibitor of Neuronal Nitric Oxide Synthase, PIN, DLC1, DNCL1, DNCLC1, HDLC1)

DYNLL1, also known as DLC8 or PIN (protein inhibitor of neuronal nitric oxide synthase), has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Binding of this protein destabilizes NOS1(Neuronal nitric oxide synthase) dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain.

Source:
Recombinant corresponding to aa1-89 of human DYNLL1 protein, fused to His-tag at N-terminus, expressed in E.coli.

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG

Molecular Weight: 12.5kD (109aa) confirmed by MALDI-TOF

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.