E7 Recombinant Protein
Référence OPCA02947-20UG
Conditionnement : 20ug
Marque : Aviva Systems Biology
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947)
| Datasheets/Manuals | Printable datasheet for E7 Recombinant Protein (Human papillomavirus type 18) (OPCA02947) |
|---|
| Predicted Species Reactivity | Human papillomavirus type 18|Human Papillomavirus Type 18 |
|---|---|
| Product Format | Liquid or Lyophilized powder |
| Reconstitution and Storage | -20°C or -80°C |
| Peptide Sequence | MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ |
| Source | Yeast |
| Protein Name | Protein E7 |
|---|---|
| Description of Target | Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26405230). |
| Uniprot ID | P06788 |
| Protein Size (# AA) | Full Length |
| Molecular Weight | 14 kDa |