EDG2 Antibody
Référence MBS8582786-0,1mL-PE
Conditionnement : 0.1mL(PE)
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
EDG2 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582786MBS8582786 is an antibody targeting EDG2. Also known as EDG2 Antibody. Reactive in Human, Mouse, Rat, Bovine, Sheep. Host: Rabbit. Rabbit polyclonal antibody to EDG2 More details
Product Overview
Online Datasheet in PDFProduct Name
EDG2, Polyclonal Antibody
Full Product Name
EDG2 Antibody
Product Gene Name
anti-EDG2 antibody
Product Synonym Gene Name
LPAR1
Product Synonym Names
EDG2; LPA1; Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of EDG2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
41,109 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (113636054..113800365, complement). Location: 9q31.3
OMIM
602282
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human EDG2. The exact sequence is proprietary.
Product Categories/Family for anti-EDG2 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EDG2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-EDG2 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-EDG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for EDG2. It may not necessarily be applicable to this product.
NCBI Official Full Name
lysophosphatidic acid receptor 1
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 1
NCBI Official Symbol
LPAR1
NCBI Official Synonym Symbols
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
UniProt Protein Name
Lysophosphatidic acid receptor 1
UniProt Synonym Protein Names
Lysophosphatidic acid receptor Edg-2
UniProt Gene Name
LPAR1
UniProt Synonym Gene Names
EDG2; LPA1; LPA receptor 1; LPA-1
UniProt Entry Name
LPAR1_HUMAN
NCBI Protein Information
lysophosphatidic acid receptor 1; LPA-1; LPA receptor 1; ventricular zone gene 1; lysophosphatidic acid receptor Edg-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
NCBI Summary for EDG2
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
Show more UniProt Comments for EDG2
LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component: cell surface; endocytic vesicle; integral to plasma membrane; plasma membrane; dendritic spine; dendritic shaft
Molecular Function: G-protein coupled receptor activity; protein binding; phospholipid binding; G-protein alpha-subunit binding; PDZ domain binding
Biological Process: myelination; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; positive regulation of apoptosis; phospholipase C activation; positive regulation of Rho protein signal transduction; bleb formation
Show more Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component: cell surface; endocytic vesicle; integral to plasma membrane; plasma membrane; dendritic spine; dendritic shaft
Molecular Function: G-protein coupled receptor activity; protein binding; phospholipid binding; G-protein alpha-subunit binding; PDZ domain binding
Biological Process: myelination; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; positive regulation of apoptosis; phospholipase C activation; positive regulation of Rho protein signal transduction; bleb formation
Research Articles on EDG2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-EDG2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Gap Junction Pathway antibodies | Gap Junction Pathway Diagram |
| Gap Junction Pathway antibodies | Gap Junction Pathway Diagram |
| Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies | Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram |
| LPA Receptor Mediated Events Pathway antibodies | LPA Receptor Mediated Events Pathway Diagram |
| Lysosphingolipid And LPA Receptors Pathway antibodies | Lysosphingolipid And LPA Receptors Pathway Diagram |
Diseases associated with anti-EDG2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >12 publications with EDG2 and Neoplasms |
| Nervous System Diseases Antibodies | >4 publications with EDG2 and Nervous System Diseases |
| Liver Neoplasms Antibodies | >3 publications with EDG2 and Liver Neoplasms |
| Inflammation Antibodies | >3 publications with EDG2 and Inflammation |
| Liver Diseases Antibodies | >3 publications with EDG2 and Liver Diseases |
| Adenocarcinoma Antibodies | >3 publications with EDG2 and Adenocarcinoma |
| Disease Models, Animal Antibodies | >3 publications with EDG2 and Disease Models, Animal |
| Carcinoma, Hepatocellular Antibodies | >2 publications with EDG2 and Carcinoma, Hepatocellular |
| Neoplasms, Experimental Antibodies | >2 publications with EDG2 and Neoplasms, Experimental |
| Lung Neoplasms Antibodies | >2 publications with EDG2 and Lung Neoplasms |
Organs/Tissues associated with anti-EDG2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Uterus Antibodies | >5 publications with EDG2 and Uterus |
| Liver Antibodies | >5 publications with EDG2 and Liver |
| Lung Antibodies | >4 publications with EDG2 and Lung |
| Heart Antibodies | >3 publications with EDG2 and Heart |
| Prostate Antibodies | >2 publications with EDG2 and Prostate |
| Vascular Antibodies | >2 publications with EDG2 and Vascular |
| Nerve Antibodies | >2 publications with EDG2 and Nerve |
| Placenta Antibodies | >2 publications with EDG2 and Placenta |
| Connective Tissue Antibodies | >2 publications with EDG2 and Connective Tissue |
| Ear Antibodies | >1 publications with EDG2 and Ear |