EEF2K (pS366) Antibody
Référence MBS8581984-0,1mL-HRP
Conditionnement : 0.1mL(HRP)
Marque : MyBiosource
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EEF2K Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8581984MBS8581984 is an antibody targeting EEF2K. Also known as EEF2K (pS366) Antibody. Reactive in Human, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to EEF2K (pS366) More details
Product Overview
Online Datasheet in PDFProduct Name
EEF2K, Polyclonal Antibody
Full Product Name
EEF2K (pS366) Antibody
Product Gene Name
anti-EEF2K antibody
Product Synonym Names
Eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of EEF2K (pS366) protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
82,144 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (22217592..22300066). Location: 16p12.2
OMIM
606968
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human EEF2K (pS366). The exact sequence is proprietary.
Product Categories/Family for anti-EEF2K antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EEF2K antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EEF2K antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-EEF2K antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for EEF2K. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
eukaryotic elongation factor 2 kinase
NCBI Official Synonym Full Names
eukaryotic elongation factor-2 kinase
NCBI Official Symbol
EEF2K
NCBI Official Synonym Symbols
eEF-2K; HSU93850
UniProt Protein Name
Eukaryotic elongation factor 2 kinase
UniProt Synonym Protein Names
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Protein Family
Eukaryotic elongation factor 2 kinase
UniProt Gene Name
EEF2K
UniProt Synonym Gene Names
eEF-2 kinase; eEF-2K
UniProt Entry Name
EF2K_HUMAN
NCBI Protein Information
eukaryotic elongation factor 2 kinase; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; calmodulin-dependent protein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-depende
NCBI Summary for EEF2K
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for EEF2K
EEF2K: an atypical protein kinase of the Alpha family. Dependent on Ca2 ions and calmodulin. May play a key role linking cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy. Phosphorylates and inactivates eEF2, resulting in the inhibition of peptide-chain elongation eEF2K is phosphorylated and activated by AMPK in response to elevated AMP levels, which increase during cellular stress and starvation. Regulated in response to a range of stimuli including TNF-alpha. Overexpressed in breast cancer cell lines and tumors. Activated in rat glioblastoma, and growth was inhibited by the drug Rottlerin. Activity induced in ischemic heart muscle
Protein type: Kinase, protein; Translation; EC 2.7.11.20; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; Alpha family; eEF2K subfamily
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytoplasm; cytosol
Molecular Function: calmodulin binding; elongation factor-2 kinase activity; translation factor activity, nucleic acid binding; calcium ion binding; ATP binding; protein kinase activity
Biological Process: translational elongation; protein amino acid autophosphorylation; regulation of protein amino acid autophosphorylation; insulin receptor signaling pathway
Show more Protein type: Kinase, protein; Translation; EC 2.7.11.20; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; Alpha family; eEF2K subfamily
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytoplasm; cytosol
Molecular Function: calmodulin binding; elongation factor-2 kinase activity; translation factor activity, nucleic acid binding; calcium ion binding; ATP binding; protein kinase activity
Biological Process: translational elongation; protein amino acid autophosphorylation; regulation of protein amino acid autophosphorylation; insulin receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-EEF2K antibody
| Reference Product | PubMed Publications |
|---|---|
| RPS6KA1 antibody | >3 publications with EEF2K and RPS6KA1 |
| MAPKAPK5 antibody | >1 publications with EEF2K and MAPKAPK5 |
| MAPKAPK3 antibody | >1 publications with EEF2K and MAPKAPK3 |
| MAPKAPK2 antibody | >1 publications with EEF2K and MAPKAPK2 |
Diseases associated with anti-EEF2K antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >15 publications with EEF2K and Neoplasms |
| Hypertrophy Antibodies | >5 publications with EEF2K and Hypertrophy |
| Nervous System Diseases Antibodies | >5 publications with EEF2K and Nervous System Diseases |
| Cardiovascular Diseases Antibodies | >3 publications with EEF2K and Cardiovascular Diseases |
| Atrophy Antibodies | >3 publications with EEF2K and Atrophy |
| Brain Diseases Antibodies | >3 publications with EEF2K and Brain Diseases |
| Necrosis Antibodies | >3 publications with EEF2K and Necrosis |
| Heart Diseases Antibodies | >2 publications with EEF2K and Heart Diseases |
| Neoplasms, Experimental Antibodies | >1 publications with EEF2K and Neoplasms, Experimental |
| Depressive Disorder Antibodies | >1 publications with EEF2K and Depressive Disorder |
Organs/Tissues associated with anti-EEF2K antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >20 publications with EEF2K and Brain |
| Muscle Antibodies | >19 publications with EEF2K and Muscle |
| Blood Antibodies | >9 publications with EEF2K and Blood |
| Heart Antibodies | >8 publications with EEF2K and Heart |
| Liver Antibodies | >6 publications with EEF2K and Liver |
| Kidney Antibodies | >5 publications with EEF2K and Kidney |
| Pancreas Antibodies | >4 publications with EEF2K and Pancreas |
| Lung Antibodies | >3 publications with EEF2K and Lung |
| Skin Antibodies | >1 publications with EEF2K and Skin |
| Intestine Antibodies | >1 publications with EEF2K and Intestine |