EGFR Protein, Human, Recombinant (hFc)
Référence NB-64-56214-50ug
Conditionnement : 50ug
Marque : Neo Biotech
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EGFR Protein, Human, Recombinant (hFc)
(Synonyms: PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor) Copy Product InfoSynonyms: PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor
Catalog No. TMPY-01043 Copy Product Info
EGFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95 kDa and the accession number is P00533.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human EGF, No Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human EGFR, hFc Tag with the EC50 of 0.44 μg/ml determined by ELISA (QC Test). |
| Description | EGFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95 kDa and the accession number is P00533. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P00533 |
| Construction | Leu25-Ser645 |
| Protein Purity | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | PIG61, NISBD2, mENA, HER1, ERBB1, ERBB, epidermal growth factor receptor |
| Research Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 95 kDa (predicted); 110-140 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Keywords
PIG-61PIG 61NISBD-2NISBD 2HER-1HER 1ERBB-1ERBB 1
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Related Tags: EGFR Protein, Human, Recombinant (hFc) chemical structure | EGFR Protein, Human, Recombinant (hFc) molecular weight
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