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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Ercalcitriol [60133-18-8]

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Référence NB-64-69266-10mg

Conditionnement : 10mg

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Ercalcitriol

(Synonyms: 1α,25-Dihydroxy Vitamin D2) Copy Product Info

Synonyms: 1α,25-Dihydroxy Vitamin D2

Catalog No. TQ0216 Copy Product Info

Purity: 99.02%

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.

Cas No. 60133-18-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.02%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2 that strengthens immunity by regulating cathelicidin antimicrobial peptide (CAMP) and defensin β-4 (DEFB4) genes in normal and transformed cells, combating pathogenic infections.
In vivo	Ercalcitriol binds to vitamin D receptor (VDR), a nuclear receptor, activates the interaction between VDR and retinol X receptor (RXR) to form VDR/RXR/ cofactor complex, which binds to Vitamin D response elements in the promoter region of target genes to regulate gene transcription[3].
Synonyms	1α,25-Dihydroxy Vitamin D2

Chemical Properties

Molecular Weight	428.65
Formula	C₂₈H₄₄O₃
Cas No.	60133-18-8
Smiles	C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Relative Density.	1.066 g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (104.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3329 mL	11.6645 mL	23.3291 mL	116.6453 mL
5 mM	0.4666 mL	2.3329 mL	4.6658 mL	23.3291 mL
10 mM	0.2333 mL	1.1665 mL	2.3329 mL	11.6645 mL
20 mM	0.1166 mL	0.5832 mL	1.1665 mL	5.8323 mL
50 mM	0.0467 mL	0.2333 mL	0.4666 mL	2.3329 mL
100 mM	0.0233 mL	0.1166 mL	0.2333 mL	1.1665 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

VK2 analogErcalcitriol1alpha,25-Dihydroxy Vitamin D21a,25-Dihydroxy Vitamin D2

Related Tags: Ercalcitriol chemical structure | Ercalcitriol in vivo | Ercalcitriol formula | Ercalcitriol molecular weight