ERCC6L Polyclonal Antibody, HRP Conjugated
Référence bs-6380R-HRP
Conditionnement : 100uL
Marque : Bioss
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Applications
Predicted Reactivity
| Overview | |
| Catalog # | bs-6380R-HRP |
| Product Name | ERCC6L Polyclonal Antibody, HRP Conjugated |
| Applications | ELISA, IHC-P, IHC-F |
| Predicted Reactivity | Human, Mouse, Rat, Cow, Sheep, Pig, Horse |
| Specifications | |
| Conjugation | HRP |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human ERCC6L |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 54821 |
| Subcellular location | Nucleus |
| Synonyms | ATP dependent helicase ERCC6 like; DNA excision repair protein ERCC 6 like; ERCC 6L; ERCC6L; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; ERC6L_HUMAN. |
| Background | ERCC6L belongs to the SNF2 ATPase family and acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. It acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L may also play a role in the teratogenic action of alcohol. |
| Application Dilution | |
| ELISA | 1:500-1000 |
| IHC-P | 1:200-400 |
| IHC-F | 1:100-500 |